Results 41 to 50 of about 38,732 (245)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aerobic synthesis of N-sulfonylamidines mediated by N-heterocyclic carbene copper(I) catalysts

Beilstein Journal of Organic Chemistry, 2020
A new catalytic strategy for the one-pot synthesis of N-sulfonylamidines is described. The cationic copper(I) complexes were found to be highly active and efficient under mild conditions in air and in the absence of solvent.
Faïma Lazreg, Marie Vasseur, Alexandra M. Z. Slawin, Catherine S. J. Cazin   +3 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Recent Advances in Enhancing Functionalization of Atomically Precise Copper Hydride Clusters

Aggregate
Copper hydride clusters have become especially fascinating in the field of functional cluster‐based materials due to the various compositions and architectures as well as intriguing properties especially hydride‐related applications.
Miao‐Miao Zhang, Ting‐Ting Liang, Chong Zhang, Huanhuan Zhang, Yu‐Fan Li, Yuanyuan Li, Shuang‐Quan Zang   +6 more
doaj   +1 more source

Intermolecular addition reactions of N-alkyl-N-chlorosulfonamides to unsaturated compounds

Beilstein Journal of Organic Chemistry, 2015
N-Alkyl-N-chlorosulfonamides add to alkenes under copper(I) catalysis. In reactions of styrene derivatives with terminal double bonds the addition products were obtained in excellent yield and high regioselectivity.
Gerold Heuger, Richard Göttlich
doaj   +1 more source

FastNano Liquid: An Automated Platform for Small‐Angle X‐ray Scattering‐Based Materials Discovery

Advanced Engineering Materials, EarlyView.
We present FastNano Liquid, an automated small‐ and wide‐angle X‐ray scattering platform for the combined synthesis and characterization of (nano)materials. The platform is coupled to varied reactor workflows for both in situ studies of reaction kinetics and ex situ screening of synthesis conditions to support machine learning‐guided exploration ...
Pierre‐Baptiste Flandrin, Émeline Cournède, Jens Krarup, Michael Lesa, Foyzul Hasan, Amandine Séné, Arnaud Lahouati, David Benhaiem, Jérémie‐Luc Sanchez, Simon Delacroix, Thierry Gacoin, Fabienne Testard, Damien Faivre, David Carriere, Corinne Chevallard, Olivier Taché, Mark A. Levenstein   +16 more
wiley   +1 more source

Synthesis of Block Ceramic Catalyst Carriers Based on Natural Raw Materials and Metallurgical Slags

Chemical Engineering Transactions, 2019
For ecological catalysis, including the purification of exhaust gases, the most promising are block catalysts. The synthesis of ceramic block catalyst carrier was carried out based on classical methods of powder metallurgy, in which moulding compounds ...
Meruyert Erkinovna Utegenova, Marzhan Anuarbekovna Sadenova, Jiri Jaromir Klemes   +2 more
doaj   +1 more source

17O-EPR determination of the structure and dynamics of copper single-metal sites in zeolites

Nature Communications, 2021
The identification of catalytically active sites with atomic-scale precision occupies a central place in the theory and practice of heterogeneous catalysis.
Paolo Cleto Bruzzese, Enrico Salvadori, Stefan Jäger, Martin Hartmann, Bartolomeo Civalleri, Andreas Pöppl, Mario Chiesa   +6 more
doaj   +1 more source