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A novel copper metabolism-related signature model for predicting the prognosis, target drugs, and immunotherapy in stomach adenocarcinoma. [PDF]
Zhuang K +8 more
europepmc +1 more source
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song +14 more
wiley +1 more source
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New England Journal of Medicine, 1961
THE element copper is ubiquitously distributed on the earth's surface. Its tin alloy, bronze, has been in use for four thousand years, and the salts of the metal were employed in the therapy of eye...
S J, ADELSTEIN, B L, VALLEE
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THE element copper is ubiquitously distributed on the earth's surface. Its tin alloy, bronze, has been in use for four thousand years, and the salts of the metal were employed in the therapy of eye...
S J, ADELSTEIN, B L, VALLEE
openaire +2 more sources
Genes regulating copper metabolism
Molecular and Cellular Biochemistry, 1998The metabolism of Cu is intimately linked with its nutrition. From gut to enzymes, Cu bioavailability to key enzymes and other components operates through a complex mechanism that uses transport proteins as well as small molecular weight ligands. Steps in Cu transport through the blood, absorption by cells, and incorporation into enzymes are slowly ...
E D, Harris, Y, Qian, M C, Reddy
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Molecular Aspects of Medicine, 2005
Iron and copper are essential nutrients, excesses or deficiencies of which cause impaired cellular functions and eventually cell death. The metabolic fates of copper and iron are intimately related. Systemic copper deficiency generates cellular iron deficiency, which in humans results in diminished work capacity, reduced intellectual capacity ...
Miguel, Arredondo, Marco T, Núñez
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Iron and copper are essential nutrients, excesses or deficiencies of which cause impaired cellular functions and eventually cell death. The metabolic fates of copper and iron are intimately related. Systemic copper deficiency generates cellular iron deficiency, which in humans results in diminished work capacity, reduced intellectual capacity ...
Miguel, Arredondo, Marco T, Núñez
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Comparative metabolism of copper
Journal of the American Veterinary Medical Association, 1987Copper is required in trace amounts for many body functions. The prominent effects of Cu deficiency or Cu toxicosis differs greatly between animal species. Along with iron, Cu is necessary for the transfer of O2 via a cascade of enzymes so that energy may be available for vital body functions without overheating of the tissues through rapid oxidation ...
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Journal of the American Medical Association, 1956
Copper as a remedy for various ailments has been of interest to physicians for many hundreds of years. It was first recognized as a normal constituent of human blood in 1875, 1 but it was not until 1924 that Elvehjem and coworkers demonstrated the essential nature of copper in mammalian nutrition, particularly in erythropoiesis.
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Copper as a remedy for various ailments has been of interest to physicians for many hundreds of years. It was first recognized as a normal constituent of human blood in 1875, 1 but it was not until 1924 that Elvehjem and coworkers demonstrated the essential nature of copper in mammalian nutrition, particularly in erythropoiesis.
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Oral Contraceptives and Copper Metabolism
Nature, 1970It has been known for many years that serum copper is increased during the later stages of pregnancy. Exogenous oestrogens produce an increase in both serum copper and the copper-binding globulin ceruloplasmin and it is therefore not surprising that that all of the popular oral contraceptives containing potent synthetic oestrogens have been reported ...
M, Briggs, J, Austin, M, Staniford
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Genetic disorders of copper metabolism
Current Opinion in Pediatrics, 1994In this review we discuss four genetic disorders of copper metabolism. Wilson's disease and Indian childhood cirrhosis result from the toxic effects of copper accumulation in the liver. Menkes' disease and, most likely, occipital horn syndrome result from copper deficiency secondary to disturbances in copper transport. The recent cloning and sequencing
K, Petrukhin, T C, Gilliam
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