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Ceruloplasmin: Copper Metabolism
1980Ceruloplasmin (ferroxidase I) first described in 1948, is the blue copper-containing oxidase present in the α2-globulin fraction of human serum (see Figure 3.5, Table 3.1). Close to 95% of the serum copper is located in this fraction.(1,2) The molecular weight of the major form of ceruloplasmin, referred to as ceruloplasmin I, is 134,000 ± 3000.(3 ...
Samuel Natelson, Ethan A. Natelson
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Neurology, 1988
We describe a patient with extrapyramidal neurologic disease and an abnormal copper profile with hepatic copper accumulation, but no cirrhosis histologically, thus excluding a diagnosis of Wilson's disease (WD). We compared and highlighted the differences between similar previously reported cases of abnormal copper metabolism and true WD and suggest a ...
J, Heckmann, D, Saffer
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We describe a patient with extrapyramidal neurologic disease and an abnormal copper profile with hepatic copper accumulation, but no cirrhosis histologically, thus excluding a diagnosis of Wilson's disease (WD). We compared and highlighted the differences between similar previously reported cases of abnormal copper metabolism and true WD and suggest a ...
J, Heckmann, D, Saffer
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Cellular Copper Transport and Metabolism
Annual Review of Nutrition, 2000The transport and cellular metabolism of Cu depends on a series of membrane proteins and smaller soluble peptides that comprise a functionally integrated system for maintaining cellular Cu homeostasis. Inward transport across the plasma membrane appears to be a function of integral membrane proteins that form the channels that select Cu ions for ...
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Metabolic Disorders of Copper Metabolism
1977Copper, atomic number 29, is an extremely versatile element both outside and inside living cells. The malleability, ductility, and esthetic properties of copper have promoted its use in pottery, ornaments, and currency for centuries. During the more recent decades, the electrical conductivity of copper has had an important role in the advancement of ...
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Metallothionein in Intestinal Copper Metabolism
1979Approximately a decade after Margoshes and Vallee (1) first identified metallothionein, Evans et al. (2) suggested that this sulfhydryl-rich protein may be involved in the metabolism of copper in both the liver and the intestine. Recently, Bremner and Young (3) demonstrated that copper is bound to metallothionein in mammalian liver. Subsequently, after
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Zinc Interference With Copper Metabolism
JAMA: The Journal of the American Medical Association, 1978Elsewhere in this issue ofThe Journal, Prasad et al (p 2166) describe a manifestation of the toxic effects of zinc in humans that has not been generally appreciated. They report the occurrence of copper deficiency (hypocupremia, leukopenia, and anemia) in a patient treated with ten times the recommended dietary allowance for zinc 1 during a prolonged ...
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Copper metabolism and pediatric cholestasis
Current Opinion in Clinical Nutrition and Metabolic Care, 2011Copper is an essential trace mineral but both deficiency and toxicity need to be avoided. Copper is regulated via excretion by the biliary system and caution was recommended when administered in patients with cholestasis. Recent clinical reports indicate that despite the cholestasis, copper should not be withheld from parenteral nutrition.Transporters ...
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Copper Metabolism and Epilepsy: A Preliminary Report
Epilepsia, 1966SUMMARYA comparison is made between the total copper level in the blood of epileptic and asthmatic patients, who have got the same diet during two weeks. A significant higher copper level is found in the epileptic patients, which is a further support of the work of Canelas et al.RÉSUMÉL'auther fait une comparaison du taux de cuivre total dans le sang ...
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Dietary Copper: Cholesterol And Lipoprotein Metabolism
Annual Review of Nutrition, 1991TISSUE CHOLESTEROL LEVELS AND PLASMA LIPOPROTEIN COMPOSITION. ...... . . . . .... . . . . . ... . . . . . . .. . . . . .. ...... . . . ...... 266 Plasma and Tissue Cholesterol Concentrations 266 Plasma Lipoprotein Composition 267 CHOLESTEROL SyNTHESIS . . . . . . ...... . . . . . . . ... . . . . . . . ..... . . . . ......
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