Results 81 to 90 of about 790,983 (253)

Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma

Biological Research, 2015
BACKGROUND: Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and
Zhao Yang, Bing Zhuan, Ying Yan, Simin Jiang, Tao Wang   +4 more
doaj   +1 more source

Environmental change drives accelerated adaptation through stimulated copy number variation

PLoS Biology, 2017
Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human disorders, particularly cancer, in which CNV promotes both tumorigenesis and chemotherapy resistance.
R. Hull, Cristina Cruz, Carmen V Jack, J. Houseley   +3 more
semanticscholar   +1 more source

Systematic identification of lincRNA‐based prognostic biomarkers by integrating lincRNA expression and copy number variation in lung adenocarcinoma

International Journal of Cancer, 2018
Copy number alterations (CNAs) of lincRNAs act as one of important mechanisms in disrupting lincRNA expression which may play critical roles during tumorigenesis in lung adenocarcinoma (LUAD). The copy number alterations of lincRNAs can mark the spectrum
Li Wang, Hongying Zhao, Yingqi Xu, Jing Li, Chunyu Deng, Yulan Deng, J. Bai, Xia Li, Yun Xiao, Yunpeng Zhang   +9 more
semanticscholar   +1 more source

Adaptation by copy number variation increases insecticide resistance in fall armyworms

bioRxiv, 2019
Insecticide resistance is a major main challenge in pest control, and understanding its genetic basis is a key topic in agricultural ecology. Detoxification genes are well-known genetic elements that play a key role in adaptation to xenobiotics.
Kiwoong Nam, S. Gimenez, F. Hilliou, C. Blanco, Sabine Hänniger, A. Bretaudeau, F. Legeai, N. Negre, E. d’Alençon   +8 more
semanticscholar   +1 more source

Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa

BMC Genomics, 2018
Background Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome.
Joan Simam, Martin Rono, Joyce Ngoi, Mary Nyonda, Sachel Mok, Kevin Marsh, Zbynek Bozdech, Margaret Mackinnon   +7 more
doaj   +1 more source

Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours

Genome Biology, 2017
Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly ...
L. Harewood, L. Harewood, K. Kishore, M. Eldridge, S. Wingett, D. Pearson, S. Schoenfelder, V. Collins, P. Fraser   +8 more
semanticscholar   +1 more source

A comparison of genomic copy number calls by Partek Genomics Suite, Genotyping Console and Birdsuite algorithms to quantitative PCR

BioData Mining, 2011
Background Copy number variants are >1 kb genomic amplifications or deletions that can be identified using array platforms. However, arrays produce substantial background noise that contributes to high false discovery rates of variants.
Grayson Britney L, Aune Thomas M
doaj   +1 more source

DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects

Biomedical Journal, 2021
Ondrej Pös, J. Radvánszky, Gergely Buglyó, Zuzana Pös, Diana Rusňáková, B. Nagy, T. Szemeš   +6 more
semanticscholar   +1 more source

Editorial: Copy Number Variation in Rare Disorders

Frontiers in Genetics, 2022
Katalin Komlósi, Attila Gyenesei, Judit Bene   +2 more
doaj   +1 more source

Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome.

American Journal of Psychiatry, 2017
OBJECTIVE Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia. The aim of this study was to identify additional genetic factors (i.e., "second hits") that may contribute to ...
A. Bassett, Chelsea Lowther, D. Merico, Gregory Costain, E. Chow, Thérèse Van Amelsvoort, D. McDonald-McGinn, R. Gur, A. Swillen, M. V. D. van den Bree, K. Murphy, D. Gothelf, C. Bearden, S. Eliez, W. Kates, N. Philip, V. Sashi, L. Campbell, J. Vorstman, J. Cubells, G. Repetto, T. Simon, E. Boot, T. Heung, Rens Evers, C. Vingerhoets, E. V. van Duin, E. Zackai, E. Vergaelen, K. Devriendt, J. Vermeesch, M. Owen, C. Murphy, Elena Michaelovosky, L. Kushan, Maude Schneider, W. Fremont, T. Busa, S. Hooper, K. McCabe, Sasja N. Duijff, K. Isaev, G. Pellecchia, John Wei, Matthew J. Gazzellone, S. Scherer, B. Emanuel, T. Guo, B. Morrow, C. Marshall   +49 more
semanticscholar   +1 more source