Results 101 to 110 of about 1,208,876 (310)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Empreintes, moulages, traces : d’Orient en Occident

open access: yesIn Situ, 2016
Ruins, in the Latin and Greek acceptation of the term, are what is left of a monument or a site which was inhabited by men. Vestiges are related to ruins, but with a different meaning. Vestigia in Latin signifies footprints, just as ichné in Greek refers
Alain Schnapp
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Prepublication Copy [PDF]

open access: yes, 2007
Washington, D.C. Evans, L., M. Frick, and R. Schwing. 1990. Is It Safer to Fly or to Drive?---A Problem in Risk Communication. Risk Analysis, Vol. 10, No. 2, pp. 239-246. GAMA. 1999. 1999 General Aviation Statistical Databook. Washington, D.C.
Prepublication Copy   +1 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

0319 Transparent Paper as a Medium of Copying and Design in the Early Modern Architectural Workshop

open access: yesRIHA Journal
This article explores the use and function of the lucido technique in architectural workshops from the Renaissance through the late eighteenth century. By examining evidence from written sources and key drawing collections, the study compares the copying
Anna Bortolozzi
doaj   +1 more source

‘Palimpsesto’ cinematográfico: rescribiendo y releyendo The Tempest de William Shakespeare

open access: yesOdisea, 2017
Resumen: La reproducción audiovisual del canon literario en el ámbito anglonorteamericano implica un desafío de gran calibre ante crítica, académicos y público, resuelto con originalidad creativa y solvencia tecnológica en la adaptación cinematográfi ca ...
Francisco José Cortés Vieco
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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