Results 181 to 190 of about 1,208,876 (310)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Correction: Ishida et al. Wnt/β-Catenin Signaling Regulates Hepatitis B Virus cccDNA Levels. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 6942. [PDF]

Int J Mol Sci
Ishida A, Iwabuchi S, Li YY, Murai K, Shirasaki T, Kuroki K, Shimakami T, Nio K, Kawaguchi K, Imafuku T, Ito S, Yamashita T, Kaneko S, Yanagawa H, Matsushima K, Honda M, Hashimoto S.   +16 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Quantifying the Influence of Genetic Context on Duplicated Mammalian Genes. [PDF]

Mol Biol Evol
Moffett AS, Falcón-Cortés A, Di Pierro M.   +2 more
europepmc   +1 more source

Guiding Opinions on Implementing the Cybersecurity Multi-Level Protection System and Critical Information Infrastructure Security Protection System (2020) [PDF]

, 2020
China Copy Right and Media
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Éditorial

Perspective, 2019
Judith Delfiner
doaj   +1 more source

Digital Handwriting Kinematics and Physical Performance According to Pentagon-Copy Performance in Community-Dwelling Older Adults: Cross-Sectional Study. [PDF]

JMIR Aging
Ferrer-Ramos P, Faundez-Zanuy M, Serra-Payá N, Garnacho-Castaño MV, Girabent-Farrés M.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Original, copie, simulacre : aspects du multiple

Perspective, 2019
Richard Shiff
doaj   +1 more source