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Nature Reviews Microbiology, 2020
This study reports that extensive copy number variations occur in the presence of azole antifungal drugs in Candida albicans, which might cause phenotypic and population-level heterogeneity observed in clinical isolates.
A. Jeremy Willsey, Montana T. Morris
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This study reports that extensive copy number variations occur in the presence of azole antifungal drugs in Candida albicans, which might cause phenotypic and population-level heterogeneity observed in clinical isolates.
A. Jeremy Willsey, Montana T. Morris
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Nature Reviews Cancer, 2020
Using single-cell multiomics, Zhou et al. show that somatic copy number alterations (SCNAs) are prevalent in non-epithelial cells from colorectal cancers and normal tissues. Tumours were enriched for fibroblasts with SCNAs, in particular whole chromosome 7 gain.
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Using single-cell multiomics, Zhou et al. show that somatic copy number alterations (SCNAs) are prevalent in non-epithelial cells from colorectal cancers and normal tissues. Tumours were enriched for fibroblasts with SCNAs, in particular whole chromosome 7 gain.
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2018
Differences between genomes can be due to single nucleotide variants (SNPs), translocations, inversions and copy number variants (CNVs, gain or loss of DNA). The latter can range from sub-microscopic events to complete chromosomal aneuploidies. Small CNVs are often benign but those larger than 250 kb are strongly associated with morbid consequences ...
Aurélien, Macé +2 more
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Differences between genomes can be due to single nucleotide variants (SNPs), translocations, inversions and copy number variants (CNVs, gain or loss of DNA). The latter can range from sub-microscopic events to complete chromosomal aneuploidies. Small CNVs are often benign but those larger than 250 kb are strongly associated with morbid consequences ...
Aurélien, Macé +2 more
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2010
Recent genetic epidemiology studies have been dominated by genome-wide association (GWA) studies using single nucleotide polymorphisms (SNPs). However, a form of structural genomic variation, termed copy number variation (CNV), is also widespread throughout the human genome, and can be highly polymorphic between individuals.
Wain, LV, Tobin, MD
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Recent genetic epidemiology studies have been dominated by genome-wide association (GWA) studies using single nucleotide polymorphisms (SNPs). However, a form of structural genomic variation, termed copy number variation (CNV), is also widespread throughout the human genome, and can be highly polymorphic between individuals.
Wain, LV, Tobin, MD
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2011
The progression of cytogenetics from banded chromosomes to DNA segment dosage as detected by comparative genomic hybridization-microarray analysis (aCGH, also abbreviated as CMA) has greatly increased the frequency of positive findings and difficulties of interpretation. The technique of aCGH (Fig.
Herman E. Wyandt, Vijay S. Tonk
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The progression of cytogenetics from banded chromosomes to DNA segment dosage as detected by comparative genomic hybridization-microarray analysis (aCGH, also abbreviated as CMA) has greatly increased the frequency of positive findings and difficulties of interpretation. The technique of aCGH (Fig.
Herman E. Wyandt, Vijay S. Tonk
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Correcting CRISPR for copy number
Nature Genetics, 2017The CRISPR-Cas9 system enables global screens of gene function with high sensitivity and specificity, but off-target effects have been reported for CRISPR guide RNAs targeting genes that are amplified at high copy number. A new study describes a computational approach to correct for this copy number effect, increasing the specificity of CRIPSR screens ...
John Paul, Shen, Trey, Ideker
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Plasmid, 1987
A low copy number cosmid was constructed by subcloning the pair of cos sites and the kanamycin resistance gene of pcos2EMBL into pGB2. The resulting cosmid, pPR691, has the pSC101 replicon and specifies resistance to kanamycin, spectinomycin, and streptomycin.
X M, Jiang +3 more
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A low copy number cosmid was constructed by subcloning the pair of cos sites and the kanamycin resistance gene of pcos2EMBL into pGB2. The resulting cosmid, pPR691, has the pSC101 replicon and specifies resistance to kanamycin, spectinomycin, and streptomycin.
X M, Jiang +3 more
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Copy Number Variants and Pharmacogenomics
Pharmacogenomics, 2005The earliest pharmacogenomic studies focused on highly penetrant sequence polymorphisms in drug-metabolizing enzymes. The recent discovery of the widespread occurrence of copy number variants/polymorphisms in the human genome holds promise for new pharmacogenomic discoveries, aside from the commonly used single nucleotide polymorphism approach. Here we
Karim, Ouahchi +2 more
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