Results 1 to 10 of about 1,744 (114)

The Roles of the Fluorescent In Situ Hybridization (FISH) and Comparative Genomic Hybridization (CGH) Techniques in the Detection of the Breast Cancer

Biology, Medicine & Natural Product Chemistry, 2022
This paper aimed to understand and compare the two popular cytogenetic techniques of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) in detecting breast cancer chromosomal abnormality.
Harem Othman Smail
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Comparative genomic hybridization

Annual Review of Genomics and Human Genetics, 2005
▪ Abstract  Altering DNA copy number is one of the many ways that gene expression and function may be modified. Some variations are found among normal individuals ( 14 , 35 , 103 ), others occur in the course of normal processes in some species ( 33 ), and still others participate in causing various disease states.
Daniel, Pinkel, Donna G, Albertson
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Comparative Genomic Hybridization (CGH) in Genotoxicology [PDF]

, 2013
In the past two decades comparative genomic hybridization (CGH) and array CGH have become crucial and indispensable tools in clinical diagnostics. Initially developed for the genome-wide screening of chromosomal imbalances in tumor cells, CGH as well as array CGH have also been employed in genotoxicology and most recently in toxicogenomics.
Baumgartner, Adi, Hartleb, Veronika, Taylor, Jim   +2 more
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Application of array comparative genomic hybridization in Korean children under 6 years old with global developmental delay [PDF]

Korean Journal of Pediatrics, 2017
PurposeRecent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of
Kyung Yeon Lee, Eunsim Shin
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Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin’s lymphoma by array-based comparative genomic hybridization

Haematologica, 2008
Background Cytogenetic analysis of classical Hodgkin’s lymphoma is limited by the low content of the neoplastic Hodgkin-Reed-Sternberg cells in the affected tissues. However, available cytogenetic data point to an extreme karyotype complexity.
Sylvia Hartmann, José I. Martin-Subero, Stefan Gesk, Julia Hüsken, Maciej Giefing, Inga Nagel, Jennifer Riemke, Andreas Chott, Wolfram Klapper, Marie Parrens, Jean-Philippe Merlio, Ralf Küppers, Andreas Bräuninger, Reiner Siebert, Martin-Leo Hansmann   +14 more
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Reporting Unwelcome Unanticipated Findings of Diagnostic Genomic Studies

Voices in Bioethics, 2014
The introduction of comparative genomic hybridization has revolutionized clinical genetics. It is used as a routine approach to the workup of developmental delays and multiple malformations.1-3 By subdividing chromosomes into their submicroscopic ...
Brian James Hanrahan, Robert Roger Lebel
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A new case of de novo chromosome 19p13.12 deletion in an Omani girl with multiple congenital anomalies: a first case report from Oman

Journal of Biochemical and Clinical Genetics, 2018
Background: This report provides a molecular cytogenetic characterization of an Omani girl with 19p13.12 microdeletion and compares her clinical features of global developmental delay (GDD) and multiple congenital anomalies with the gene mutations and ...
Musallam Said Al-Araimi, Aliya Mahmood Al-Hosni, Ali Ahmed Al-Yahmadi, Salma Mohammed Al-Harasi   +3 more
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Findings from ACGH in patient with psychomotor delay-case report

Genetics & Applications, 2019
Initial testing of children with psychomotor delays considers karyotype analysis and metabolic tests. However, introduction of Array Comparative Genomic Hybridization (ACGH) has become the standard method of diagnostics worldwide.
Vanja Vidović, Nela Maksimović, Tatjana Damnjanović, Biljana Jekić, Irina Milovac, Milka Grk, Stojko Vidović   +6 more
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Comparative Genomic Hybridization

Archives of Pathology & Laboratory Medicine, 2001
Comparative genomic hybridization (CGH) allows a genome-wide survey of the relative copy number of tumor DNA in a single hybridization. The tumor-cell DNA (Test DNA) is hybridized together with a sex-matched normal DNA (Reference DNA) onto normal metaphase spreads.
I J, Barrett, B L, Lomax, T, Loukianova, S S, Tang, V S, Lestou, D K, Kalousek   +5 more
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Invasive melanoma in a 5-year-old Canadian patient: A case report

SAGE Open Medical Case Reports, 2019
Atypical Spitzoid lesions pose a distinct challenge in classification as they may comprise a mixture of both classic benign nevus and cutaneous melanoma characteristics.
Joanna Yuen, Fatmah AlZahrani, Garnet Horne, Karen Naert, Timothy McCalmont, Kathy Unger, Loretta Fiorillo   +6 more
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