Results 1 to 10 of about 175,678 (179)

Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis [PDF]

Journal of Ovarian Research
Background Teratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of teratomas may provide a better understanding of their stepwise differentiation processes and molecular ...
Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Yen-Chein Lai   +3 more
doaj   +2 more sources

The Roles of the Fluorescent In Situ Hybridization (FISH) and Comparative Genomic Hybridization (CGH) Techniques in the Detection of the Breast Cancer

Biology, Medicine & Natural Product Chemistry, 2022
This paper aimed to understand and compare the two popular cytogenetic techniques of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) in detecting breast cancer chromosomal abnormality.
Harem Othman Smail
doaj   +1 more source

Comparative genomic hybridization

Annual Review of Genomics and Human Genetics, 2005
▪ Abstract  Altering DNA copy number is one of the many ways that gene expression and function may be modified. Some variations are found among normal individuals ( 14 , 35 , 103 ), others occur in the course of normal processes in some species ( 33 ), and still others participate in causing various disease states.
Daniel, Pinkel, Donna G, Albertson
openaire   +3 more sources

Microarray-based ultra-high resolution discovery of genomic deletion mutations [PDF]

, 2014
BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations.
Baban, D., Belfield, E., Brown, C., Gan, X., Harberd, N., Jiang, C., Mithani, A., Mott, R., Ragoussis, J.   +8 more
core   +6 more sources

Application of array comparative genomic hybridization in Korean children under 6 years old with global developmental delay [PDF]

Korean Journal of Pediatrics, 2017
PurposeRecent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of
Kyung Yeon Lee, Eunsim Shin
doaj   +1 more source

Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin’s lymphoma by array-based comparative genomic hybridization

Haematologica, 2008
Background Cytogenetic analysis of classical Hodgkin’s lymphoma is limited by the low content of the neoplastic Hodgkin-Reed-Sternberg cells in the affected tissues. However, available cytogenetic data point to an extreme karyotype complexity.
Sylvia Hartmann, José I. Martin-Subero, Stefan Gesk, Julia Hüsken, Maciej Giefing, Inga Nagel, Jennifer Riemke, Andreas Chott, Wolfram Klapper, Marie Parrens, Jean-Philippe Merlio, Ralf Küppers, Andreas Bräuninger, Reiner Siebert, Martin-Leo Hansmann   +14 more
doaj   +1 more source

Comparative Genomic Hybridization

Archives of Pathology & Laboratory Medicine, 2001
Comparative genomic hybridization (CGH) allows a genome-wide survey of the relative copy number of tumor DNA in a single hybridization. The tumor-cell DNA (Test DNA) is hybridized together with a sex-matched normal DNA (Reference DNA) onto normal metaphase spreads.
Irene J. Barrett, Brenda L. Lomax, Tatiana Loukianova, Steven S. Tang, Valia S. Lestou, Dagmar K. Kalousek   +5 more
openaire   +3 more sources

Reporting Unwelcome Unanticipated Findings of Diagnostic Genomic Studies

Voices in Bioethics, 2014
The introduction of comparative genomic hybridization has revolutionized clinical genetics. It is used as a routine approach to the workup of developmental delays and multiple malformations.1-3 By subdividing chromosomes into their submicroscopic ...
Brian James Hanrahan, Robert Roger Lebel
doaj   +1 more source

Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumors by comparative genomic hybridization after universal DNA-amplification [PDF]

, 1993
We present a technique which allows the detection and chromosomal localization of DNA sequence copy number changes in solid tumor genomes from frozen sections and paraffin embedded, formalin fixed specimens. Based on comparative genomic hybridization and
Cremer, Thomas, Holtgreve-Grez, Heidi, Lengauer, Christoph, Manoir, Stanislas du, Ried, Thomas, Schoell, B., Schröck, Evelin, Speicher, Michael R.   +7 more
core   +1 more source

A new case of de novo chromosome 19p13.12 deletion in an Omani girl with multiple congenital anomalies: a first case report from Oman

Journal of Biochemical and Clinical Genetics, 2018
Background: This report provides a molecular cytogenetic characterization of an Omani girl with 19p13.12 microdeletion and compares her clinical features of global developmental delay (GDD) and multiple congenital anomalies with the gene mutations and ...
Musallam Said Al-Araimi, Aliya Mahmood Al-Hosni, Ali Ahmed Al-Yahmadi, Salma Mohammed Al-Harasi   +3 more
doaj   +1 more source