Results 1 to 10 of about 502,591 (164)
TUBA1A-GLI1 fusion in a soft tissue myoepithelial neoplasm
Human Pathology: Case Reports, 2021 Several types of benign and malignant neoplasms harboring GLI1 gene fusions with various partner genes, including ACTB, MALAT1 and PTCH1, have been described.
Yajuan J. Liu +3 more
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Diagnostics, 2022 Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal ...
Gregor Hoermann
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HYPERMETHYLATION OF DNA REPAIR GENES IS LINKED TO PROGNOSIS OF MYELODYSPLASTIC NEOPLASM
Hematology, Transfusion and Cell Therapy, 2023 Introduction: Myelodysplastic Neoplasm (MDS) is an age-associated neoplasia characterized by frequent epigenetic abnormalities. Hypermethylation of gene promoter sites is common in MDS and increases in advanced stages of the disease, which may be related
MA Viana +9 more
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Diagnosis of lung squamous cell carcinoma based on metagenomic Next-Generation Sequencing
BMC Pulmonary Medicine, 2022 Background The clinical treatment of patients suspected of pulmonary infections often rely on empirical antibiotics. However, preliminary diagnoses were based on clinical manifestations and conventional microbiological tests, which could later be proved ...
Ping Wei +9 more
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Frontiers in Pharmacology, 2021 Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic
Ruizheng Sun +16 more
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DNA repair and damage pathways in mesothelioma development and therapy
Cancer Cell International, 2022 Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis.
Faezeh Malakoti +11 more
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A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation
BMC Cancer, 2023 SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across ...
Hira Javaid +9 more
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Hematology, Transfusion and Cell Therapy, 2023 Introduction: Myelodysplastic Neoplasm (MDS) is characterized by cytogenetic alterations in 40-60% of cases and 94% have at least one oncogenic mutation.
RTG Oliveira +9 more
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Clinical experience of immune checkpoint inhibitor for a metastatic jejunal cancer patient with a high tumor mutational burden and low expression of programmed death-ligand 1 [PDF]
Korean Journal of Clinical Oncology, 2020 Recent data showed that DNA mismatch repair deficiency can be a predictive biomarker for a favorable response of immune checkpoint inhibitors regardless of tumor type due to give rise to high tumor mutational burden (TMB) and microsatellite instability ...
Seo Ree Kim +6 more
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Aggressive NK-cell leukemia: A rare entity with diagnostic and therapeutic challenge
Human Pathology: Case Reports, 2016 Aggressive natural killer cell leukemia (ANKL) is a rare neoplasm of mature natural killer cells, with an extremely poor overall survival, which is almost always EBV related, with majority of cases reported in East Asia.
Alia Nazarullah +4 more
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