Results 11 to 20 of about 2,091,584 (306)

Atypical fibroxanthoma: An unusual skin neoplasm in xeroderma pigmentosum

Indian Journal of Dermatology, 2012
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder related to defective deoxyribonucleic acid (DNA) repair. Various cutaneous manifestations related to ultraviolet (UV) damage characterize the clinical course.
Ranjana Bandyopadhyay, Dipanwita Nag, Sanjay Bandyopadhyay, Swapan Kumar Sinha   +3 more
doaj   +2 more sources

A Comprehensive Microarray-Based DNA Methylation Study of 367 Hematological Neoplasms

PLoS ONE, 2009
Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities, and comprehensive studies are required.Here, we report for the first time a microarray-based DNA methylation ...
Martin-Subero, Jose Ignacio, Ammerpohl, Ole, Bibikova, Marina, Wickham-Garcia, Eliza, Agirre, Xabier, Alvarez, Sara, Brüggemann, Monika, Bug, Stefanie, Calasanz, Maria J., Deckert, Martina, Dreyling, Martin, Du, Ming Q., Dürig, Jan, Dyer, Martin J. S., Fan, Jian-Bing, Gesk, Stefan, Hansmann, Martin-Leo, Harder, Lana, Hartmann, Sylvia, Klapper, Wolfram, Küppers, Ralf, Montesinos-Rongen, Manuel, Nagel, Inga, Pott, Christiane, Richter, Julia, Román-Gómez, José, Seifert, Marc, Stein, Harald, Suela, Javier, Trümper, Lorenz, Vater, Inga, Prosper, Felipe, Haferlach, Claudia, Cruz Cigudosa, Juan, Siebert, Reiner   +34 more
core   +11 more sources

DNA Copy Number Losses in Human Neoplasms [PDF]

The American Journal of Pathology, 1999
This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.
S, Knuutila, Y, Aalto, K, Autio, A M, Björkqvist, W, El-Rifai, S, Hemmer, T, Huhta, E, Kettunen, S, Kiuru-Kuhlefelt, M L, Larramendy, T, Lushnikova, O, Monni, H, Pere, J, Tapper, M, Tarkkanen, A, Varis, V M, Wasenius, M, Wolf, Y, Zhu   +18 more
openaire   +2 more sources

Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms [PDF]

Genome Research, 2021
Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA methylation. Examining the global mechanism of action of HC in the context of myeloproliferative neoplasms (MPNs), for ...
Stephania Contreras Castillo, Bertille Montibus, Azucena Rocha, Will Duke, Ferdinand von Meyenn, Donal McLornan, Claire Harrison, Ann Mullally, Reiner Schulz, Rebecca J. Oakey   +9 more
openaire   +5 more sources

Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia. [PDF]

PLoS ONE, 2015
Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is an intractable pediatric myeloid neoplasm. Epigenetic regulation of transcription, particularly by CpG methylation, plays an important role in tumor ...
Hirotoshi Sakaguchi, Hideki Muramatsu, Yusuke Okuno, Hideki Makishima, Yinyan Xu, Yoko Furukawa-Hibi, Xinan Wang, Atsushi Narita, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Nao Yoshida, Asahito Hama, Yoshiyuki Takahashi, Kiyofumi Yamada, Satoru Miyano, Seishi Ogawa, Jaroslaw P Maciejewski, Seiji Kojima   +18 more
doaj   +1 more source

WHO HAS THERAPY-RELATED AML?

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Therapy-related leukemia or therapy-related myeloid neoplasm are widely-used terms to designate leukemia developing in persons who previously received anti-cancer therapy (for example, see references 1, 2), especially if the prior anti-cancer therapy ...
Robert Gale, John M. Bennett, F. Owen Hoffman   +2 more
doaj   +1 more source

Evaluation of clinical value and potential mechanism of MTFR2 in lung adenocarcinoma via bioinformatics

BMC Cancer, 2021
Background Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported.
Cheng Chen, Yang Tang, Wen-Dong Qu, Xu Han, Jie-Bin Zuo, Qing-Yong Cai, Gang Xu, Yong-Xiang Song, Xi-Xian Ke   +8 more
doaj   +1 more source

DNA methylation and carcinogenesis in digestive neoplasms

World Journal of Gastroenterology, 1998
. Newly replicated DNA lacks thismethylation in the nascent strand. Shortly after thepassage of the replication fork, a maintenanceDNA-MTase methylates CpG dinucleotides on thenewly synthesized strand, thereby recreating thespectrum of methyl groups that existed prior toreplication.
Javed, Yakoob, Xue-Gong, Fan, Guo-Ling, Hu, Zheng, Zhang   +3 more
openaire   +2 more sources

DNA copy number amplification profiling of human neoplasms [PDF]

Oncogene, 2006
DNA copy number amplifications activate oncogenes and are hallmarks of nearly all advanced tumors. Amplified genes represent attractive targets for therapy, diagnostics and prognostics. To investigate DNA amplifications in different neoplasms, we performed a bibliomics survey using 838 published chromosomal comparative genomic hybridization studies and
S, Myllykangas, J, Himberg, T, Böhling, B, Nagy, J, Hollmén, S, Knuutila   +5 more
openaire   +2 more sources

A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure [PDF]

, 2022
Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment ...
Lim, Y., Paton, S., Cakouros, D., Campbell, David, Lim, Yoon, Tran, E.N.H., Gronthos, S., Thompson-Peach, C., Kutyna, Monika M., Kutyna, M.M., Arthur, A., Tran, Elizabeth Ngoc Hoa, Kumar, Sharad, Arthur, Agnes, Hiwase, D.K., Hughes, T., Hiwase, Devendra K., Kumar, S., Thompson-Peach, Chloe, Thomas, Daniel, Cakouros, Dimitrios, Lim, Kelly, Kok, C.H., Gronthos, Stan, Campbell, D., Kok, Chung Hoow, Paton, Sharon, Hughes, Timothy, Lim, K., Thomas, D.   +29 more
core   +1 more source