Results 11 to 20 of about 479,747 (308)
A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation [PDF]
BMC Cancer, 2023 SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across ...
Hira Javaid +9 more
doaj +5 more sources
Atypical fibroxanthoma: An unusual skin neoplasm in xeroderma pigmentosum
Indian Journal of Dermatology, 2012 Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder related to defective deoxyribonucleic acid (DNA) repair. Various cutaneous manifestations related to ultraviolet (UV) damage characterize the clinical course.
Ranjana Bandyopadhyay +3 more
doaj +2 more sources
Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia. [PDF]
PLoS ONE, 2015 Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is an intractable pediatric myeloid neoplasm. Epigenetic regulation of transcription, particularly by CpG methylation, plays an important role in tumor ...
Hirotoshi Sakaguchi +18 more
doaj +3 more sources
Dependence of DNA-Histograms on The Sampling Techniques in Fine Needle Aspirates of the Breast
Analytical Cellular Pathology, 2002 48 fine needle aspiration biopsy (FNAB) samples from 25 breast cancer cases, originally used for cytodiagnosis were subjected to DNA cytometry. There were air dried smears stained with the MGG method, and samples stained with HE or PAP stain after 50 ...
A. Elzagheid, Y. Collan
doaj +2 more sources
Cancer Medicine, 2019 Intraductal papillary mucinous neoplasm (IPMN) of pancreas has a high risk to develop into invasive cancer or co‐occur with malignant lesion. Therefore, it is important to assess its malignant risk by less‐invasive approach.
Raúl N. Mateos +16 more
doaj +2 more sources
TUBA1A-GLI1 fusion in a soft tissue myoepithelial neoplasm
Human Pathology: Case Reports, 2021 Several types of benign and malignant neoplasms harboring GLI1 gene fusions with various partner genes, including ACTB, MALAT1 and PTCH1, have been described.
Yajuan J. Liu +3 more
doaj +1 more source
A Deep Embedded Framework for Spitzoid Neoplasm Classification Using DNA Methylation Data [PDF]
, 2021 [EN] Spitzoid melanocytic tumors (SMT) are a group of neoplasms that represent a formidable diagnostic challenge for dermatopathologists. DNA methylation (DNAm) is a welldefined epigenetic factor that has an important role in the development of these ...
Colomer, Adrián +11 more
core +1 more source
Diagnostics, 2022 Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal ...
Gregor Hoermann
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HYPERMETHYLATION OF DNA REPAIR GENES IS LINKED TO PROGNOSIS OF MYELODYSPLASTIC NEOPLASM
Hematology, Transfusion and Cell Therapy, 2023 Introduction: Myelodysplastic Neoplasm (MDS) is an age-associated neoplasia characterized by frequent epigenetic abnormalities. Hypermethylation of gene promoter sites is common in MDS and increases in advanced stages of the disease, which may be related
MA Viana +9 more
doaj +1 more source
A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure [PDF]
, 2022 Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment ...
Lim, Y. +29 more
core +1 more source