Results 21 to 30 of about 479,747 (308)

Diagnosis of lung squamous cell carcinoma based on metagenomic Next-Generation Sequencing

BMC Pulmonary Medicine, 2022
Background The clinical treatment of patients suspected of pulmonary infections often rely on empirical antibiotics. However, preliminary diagnoses were based on clinical manifestations and conventional microbiological tests, which could later be proved ...
Ping Wei, Yang Gao, Jing Zhang, Jianlong Lin, Huibin Liu, Keqiang Chen, Weikai Lin, Xiaojia Wang, Chune Wang, Chao Liu   +9 more
doaj   +1 more source

Systematic Investigation of DNA Methylation Associated With Platinum Chemotherapy Resistance Across 13 Cancer Types

Frontiers in Pharmacology, 2021
Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic
Ruizheng Sun, Ruizheng Sun, Chao Du, Chao Du, Jiaxin Li, Jiaxin Li, Yanhong Zhou, Yanhong Zhou, Wei Xiong, Wei Xiong, Juanjuan Xiang, Juanjuan Xiang, Jiheng Liu, Zhigang Xiao, Li Fang, Zheng Li, Zheng Li   +16 more
doaj   +1 more source

DNA Copy Number Losses in Human Neoplasms [PDF]

The American Journal of Pathology, 1999
This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.
S, Knuutila, Y, Aalto, K, Autio, A M, Björkqvist, W, El-Rifai, S, Hemmer, T, Huhta, E, Kettunen, S, Kiuru-Kuhlefelt, M L, Larramendy, T, Lushnikova, O, Monni, H, Pere, J, Tapper, M, Tarkkanen, A, Varis, V M, Wasenius, M, Wolf, Y, Zhu   +18 more
openaire   +2 more sources

DNA repair and damage pathways in mesothelioma development and therapy

Cancer Cell International, 2022
Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis.
Faezeh Malakoti, Niloufar Targhazeh, Erfan Abadifard, Reza Zarezadeh, Sahar Samemaleki, Zatollah Asemi, Simin Younesi, Reza Mohammadnejad, Seyed Hadi Hossini, Ansar Karimian, Forough Alemi, Bahman Yousefi   +11 more
doaj   +1 more source

Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms [PDF]

Genome Research, 2021
Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA methylation. Examining the global mechanism of action of HC in the context of myeloproliferative neoplasms (MPNs), for ...
Stephania Contreras Castillo, Bertille Montibus, Azucena Rocha, Will Duke, Ferdinand von Meyenn, Donal McLornan, Claire Harrison, Ann Mullally, Reiner Schulz, Rebecca J. Oakey   +9 more
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SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM

Hematology, Transfusion and Cell Therapy, 2023
Introduction: Myelodysplastic Neoplasm (MDS) is characterized by cytogenetic alterations in 40-60% of cases and 94% have at least one oncogenic mutation.
RTG Oliveira, ME Escócia, LR Sampaio, DP Borges, JVC Goes, MA Viana, RDB Dias, NFAM Mendonça, SMM Magalhães, RF Pinheiro   +9 more
doaj   +1 more source

Clinical experience of immune checkpoint inhibitor for a metastatic jejunal cancer patient with a high tumor mutational burden and low expression of programmed death-ligand 1 [PDF]

Korean Journal of Clinical Oncology, 2020
Recent data showed that DNA mismatch repair deficiency can be a predictive biomarker for a favorable response of immune checkpoint inhibitors regardless of tumor type due to give rise to high tumor mutational burden (TMB) and microsatellite instability ...
Seo Ree Kim, Sang Hoon Chun, Ji Hyun Kim, Sang-Yeob Kim, Bo-In Lee, Chan Kwon Jung, Jin Hyoung Kang   +6 more
doaj   +1 more source

Aggressive NK-cell leukemia: A rare entity with diagnostic and therapeutic challenge

Human Pathology: Case Reports, 2016
Aggressive natural killer cell leukemia (ANKL) is a rare neoplasm of mature natural killer cells, with an extremely poor overall survival, which is almost always EBV related, with majority of cases reported in East Asia.
Alia Nazarullah, Michelle Don, Yuliya Linhares, Serhan Alkan, Qin Huang   +4 more
doaj   +1 more source

DNA copy number amplification profiling of human neoplasms [PDF]

Oncogene, 2006
DNA copy number amplifications activate oncogenes and are hallmarks of nearly all advanced tumors. Amplified genes represent attractive targets for therapy, diagnostics and prognostics. To investigate DNA amplifications in different neoplasms, we performed a bibliomics survey using 838 published chromosomal comparative genomic hybridization studies and
S, Myllykangas, J, Himberg, T, Böhling, B, Nagy, J, Hollmén, S, Knuutila   +5 more
openaire   +2 more sources

WHO HAS THERAPY-RELATED AML?

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Therapy-related leukemia or therapy-related myeloid neoplasm are widely-used terms to designate leukemia developing in persons who previously received anti-cancer therapy (for example, see references 1, 2), especially if the prior anti-cancer therapy ...
Robert Gale, John M. Bennett, F. Owen Hoffman   +2 more
doaj   +1 more source