Results 41 to 50 of about 2,091,584 (306)

Evaluation of Methylation Status in the 5'UTR Promoter Region of the DBC2 Gene as a Biomarker in Sporadic Breast Cancer [PDF]

Cell Journal, 2012
Objective: Breast cancer is one of the most common malignancies in women worldwide. It is caused by a number of genetic and epigenetic factors. Aberrant hypermethylation of the promoter regions in specific genes is a key event in the formation and ...
Ali Bidmeshki-Pour, Mousa Keyhanee, Yousef Shafeghati, Hamid Karbassian, Mehrdad Noruzinia, Mehri Hajikhan Mirzaei   +5 more
doaj  

Using cell-free RNA to identify B- and T-cell clonality for diagnosis and monitoring of B- and T-cell neoplasms. [PDF]

FEBS Open Bio
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Albitar A, Agersborg S, Charifa A, Phull P, Biran N, Vesole D, Parmar H, Pecora A, Ip A, Goy A, Siegel D, Albitar M.   +11 more
europepmc   +2 more sources

Attitudes of cancer patients toward ctDNA-based liquid biopsy for follow-up. [PDF]

Mol Oncol
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Chhajlani S, Mariën L, De Weerdt C, Wouters S, Teuwen LA, Prenen H, Janssens K, Vandamme T.   +7 more
europepmc   +2 more sources

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms

Frontiers in Oncology, 2020
The purpose of the present study was to investigate whether former childhood cancer patients who developed a subsequent secondary primary neoplasm (SPN) are characterized by elevated spontaneous chromosomal instability or cellular and chromosomal ...
Sebastian Zahnreich, Alicia Poplawski, Carola Hartel, Lukas Stefan Eckhard, Danuta Galetzka, Thomas Hankeln, Markus Löbrich, Manuela Marron, Johanna Mirsch, Sylvia Ritter, Peter Scholz-Kreisel, Claudia Spix, Heinz Schmidberger   +12 more
doaj   +1 more source

Ileocecal Intussusception Caused by an Appendiceal Neoplasm

, 2016
Mucinous appendiceal neoplasm occurs in less than 1 % of appendicectomies. Majority of what is known in the literature is about pseudomyxoma peritonei, which exists as its disseminated form.
Gill, P, Samra, JS, Gill, AJ, Chua, TC
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Pancreatic Intraductal Papillary Mucinous Neoplasm with Hyaline Globules (Thanatosomes): Report of Two Cases

, 2021
Mitsuhiro Tachibana,1 Ryohei Koreyasu,2 Kazuyasu Kamimura,2 Yutaka Tsutsumi1,3 1Department of Diagnostic Pathology, Shimada City General Medical Center, Shimada, Shizuoka, Japan; 2Department of Surgery, Shimada City General Medical Center, Shimada ...
Koreyasu R, Tsutsumi Y, Kamimura K, Tachibana M   +3 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source