Results 121 to 130 of about 475,380 (299)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Cell Reports, 2018
SUMMARY We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios.
Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, M. Morris, Juan Arbelaez, Cara Nasello, Shan Dong, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha S. Padmanabhuni, Dongmei Yu, Robert A. King, A. Dietrich, N. Khalifa, N. Dahl, Alden Huang, B. Neale, G. Coppola, C. Mathews, J. Scharf, T. Fernandez, J. Buxbaum, Silvia De Rubeis, D. Grice, Jinchuan Xing, G. Heiman, J. Tischfield, P. Paschou, A. Willsey, M. State, M. Abdulkadir, B. Bodmer, Y. Bromberg, Lawrence W. Brown, K. Cheon, B. Coffey, L. Deng, Lonneke Elzerman, C. Fremer, B. Garcia-Delgar, D. Gilbert, Julie Hagstrøm, T. Hedderly, I. Heyman, P. Hoekstra, H. Hong, C. Huyser, Eun-Joo Kim, Y. Kim, Young-Shin Kim, Yun-Joo Koh, S. Kook, S. Kuperman, Bennett L. Leventhal, A. Ludolph, M. Madruga‐Garrido, A. Maras, P. Mir, A. Morer, M. Morris, K. Müller-Vahl, A. Münchau, T. Murphy, K. Plessen, Hannah Poisner, Veit Roessner, Stephan J Sanders, Eun-young Shin, Dongya Song, Jungeun Song, Joshua K. Thackray, Jennifer Tübing, F. Visscher, Sina Wanderer, A. Willsey, Martin L. Woods, Yeting Zhang, S. Zinner, C. Androutsos, C. Barta, L. Farkas, J. Fichna, Marianthi Georgitsi, P. Janik, I. Karagiannidis, A. Koumoula, P. Nagy, J. Puchala, R. Rizzo, N. Szejko, U. Szymańska, Z. Tarnok, V. Tsironi, T. Wolańczyk, C. Żekanowski, C. Barr, J. Batterson, C. Berlin, R. Bruun, C. Budman, D. Cath, S. Chouinard, N. Cox, S. Darrow, L. Davis, Y. Dion, N. Freimer, M. Grados, Matthew E. Hirschtritt, C. Illmann, R. Kurlan, J. Leckman, G. Lyon, I. Malaty, William M. MacMahon, M. Okun, L. Osiecki, D. Pauls, D. Posthuma, V. Ramensky, M. Robertson, G. Rouleau, P. Sandor, H. Singer, Jan Smit, J. Sul   +127 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Causative Factors for ADHD: Role of Copy Number Variants in ADHD

Pediatric Neurology Briefs, 2014
Investigators from Brazil determined if copy number variants (CNVs) in glutamate metabotropic receptor genes (GRM) were overrepresented in 1038 individuals with ADHD compared to 1057 subjects without ADHD.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Identification of novel candidate disease genes from de novo exonic copy number variants

Genome Medicine, 2017
Exon-targeted microarrays can detect small (
T. Gambin, Bo Yuan, W. Bi, Pengfei Liu, J. Rosenfeld, Z. Coban-Akdemir, A. Pursley, S. Nagamani, Ronit Marom, Sailaja Golla, Lauren Dengle, Heather G. Petrie, R. Matalon, Lisa T. Emrick, M. Proud, D. Treadwell-Deering, Hsiao-Tuan Chao, H. Koillinen, Chester W. Brown, N. Urraca, Roya M Mostafavi, S. Bernes, E. Roeder, Kimberly Nugent, P. Bader, G. Bellus, Michael Cummings, H. Northrup, M. Ashfaq, Rachel Westman, R. Wildin, A. Beck, L. Immken, Lindsay E. Elton, Shaun Varghese, E. Buchanan, L. Faivre, Mathilde Lefebvre, C. Schaaf, M. Walkiewicz, Yaping Yang, Sung-Hae L. Kang, S. Lalani, C. Bacino, A. Beaudet, Amy M. Breman, Janice L. Smith, S. Cheung, J. Lupski, Ankita Patel, C. Shaw, P. Stankiewicz   +51 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source