Results 101 to 110 of about 272,726 (306)
Copy number variation of glyoxalase I [PDF]
, 2014 The glyoxalase I gene GLO1 is a hotspot for copy number variation in the human and mouse genomes. The additional copies are often functional, giving rise to 2–4-fold increased glyoxalase I expression and activity.
Rabbani, Naila +3 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Measurement and phenotypic consequences of ribosomal DNA copy number variation [PDF]
, 2021 Thesis (Ph.D.)--University of Washington, 2021The ribosomal DNA (rDNA) encodes the ribosomal RNAs and is present in tens to thousands of tandemly repeated copies in eukaryotic genomes.
Hall, Ashley Nicole
core +1 more source
Comprehensively benchmarking applications for detecting copy number variation.
PLoS Computational Biology, 2019 MOTIVATION:Recently, copy number variation (CNV) has gained considerable interest as a type of genomic variation that plays an important role in complex phenotypes and disease susceptibility.
Le Zhang +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Biological Research, 2015 BACKGROUND: Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and
Zhao Yang +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
SIPL1 DNA copy number variation (CNV) in ductal breast carcinoma. [PDF]
, 2015 a Invasive ductal carcinomab The Log2 copy number units reported within Oncomine, a Log2 copy number unit of 0 is converted to a gene copy number value of 2 according to the formula 2 X 2(Log2 Copy Number Units)c Statistical analysis was conducted using ...
Jason De Melo (741261) +1 more
core +1 more source
Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa
BMC Genomics, 2018 Background Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome.
Joan Simam +7 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source