Results 111 to 120 of about 272,726 (306)

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution [PDF]

, 2008
BACKGROUND: Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny.
Griffin, D.K., Gaginskaya, E., Robertson, L. B., Völker Martin, Masabanda, Julio S., Burt, D.W., Valérie Fillon, Svetlana Deryusheva, Robertson Lindsay B, Griffin Darren K, Fillon, V., Masabanda, J. S., Martin Völker, Richard Talbot, Crooijmans, Richard P.M.A., Darren K Griffin, Gaginskaya, Elena, Vignal Alain, Martien AM Groenen, Crooijmans, Richard P. M. A., Dave W Burt, Groenen, M.A.M., Burt Dave W, Robertson, L.B., Griffin, D. K., Burt, D. W., Helen G Tempest, Carre, Wilfrid, Vignal, Alain, Julio S Masabanda, Crooijmans, R.P.M.A., Burt, Dave W, Tempest, H.G., Groenen, Martien A. M., Griffin, Darren K., Deryusheva, Svetlana, Waddington David, Talbot, Richard, Waddington, D., Robertson, Lindsay B., Robertson, Lindsay, Carré Wilfrid, Masabanda, Julio S, Groenen, Martien AM, Tempest, Helen G., Gaginskaya Elena, Fillon Valérie, Burt, Dave W., Waddington, David, Tempest, H. G., Groenen Martien AM, Fillon, Valerie, Lindsay B Robertson, Talbot Richard, Crooijmans, R. P., Deryusheva, S., Elena Gaginskaya, Masabanda Julio S, Tempest Helen G, Volker, Martin, Crooijmans, Richard PMA, Groenen, M. A., David Waddington, Deryusheva Svetlana, Talbot, R., Wilfrid Carré, Richard PMA Crooijmans, Masabanda, J.S., Vignal, A., Alain Vignal, Burt, David W., Crooijmans Richard PMA, Volker, M., Carre, W.   +73 more
core   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Using the R Package crlmm for Genotyping and Copy Number Estimation [PDF]

Genotyping platforms such as Affymetrix can be used to assess genotype-phenotype as well as copy number-phenotype associations at millions of markers.
Rafael A. Irizarry, Matthew E. Ritchie, Ingo Ruczinski, Robert B. Scharpf, Benilton Carvalho   +4 more
core   +1 more source

Accurate estimation of homologue-specific DNA concentration-ratios in cancer samples allows long-range haplotyping [PDF]

, 2011
Interpretation of allelic copy measurements at polymorphic markers in cancer samples presents distinctive challenges and opportunities. Due to frequent gross chromosomal alterations occurring in cancer (aneuploidy), many genomic regions are present at ...
Gad Getz, Matthew Meyerson, Scott L. Carter   +2 more
core   +1 more source

Nanochromosome copy number variation. [PDF]

, 2013
(A) Relative nanochromosome copy number distribution (number of telomere-less reads/bp of nonsubtelomeric nanochromosome; see Materials and Methods) for homozygous matchless, heterozygous matchless, and heterozygous matching nanochromosomes.
Glenn A. Herrick (277584), Kevin Haub (277579), John C. Matese (5551), Michael S. Bowen (277582), Vincent Magrini (55436), Xiao Chen (260187), Lance Parsons (201226), Thomas A. Jones (277583), Thomas G. Doak (48083), Richard K. Wilson (13401), Laura F. Landweber (19272), Seolkyoung Jung (277576), Klaas Schotanus (277575), Aaron D. Goldman (277574), Wei-Jen Chang (48081), Jaspreet S. Khurana (235149), John R. Bracht (277573), Elaine R. Mardis (13400), Robert S. Fulton (257031), Amy Ly (277577), Estienne C. Swart (277571), Nicholas A. Stover (61257), Sean R. Eddy (5840), Yi Zhou (2723), Patrick Minx (2206), Donna Storton (277581), Sean McGrath (277578), Mariusz Nowacki (129438), Jessica L. Wiggins (277580)   +28 more
core   +1 more source

Genomic copy number variation analysis in multiple system atrophy

Molecular Brain, 2017
Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region.
Yuka Hama, Masataka Katsu, Ichigaku Takigawa, Ichiro Yabe, Masaaki Matsushima, Ikuko Takahashi, Takayuki Katayama, Jun Utsumi, Hidenao Sasaki   +8 more
doaj   +1 more source

New Copy Number Variations in Schizophrenia

PLoS ONE, 2010
Genome-wide screenings for copy number variations (CNVs) in patients with schizophrenia have demonstrated the presence of several CNVs that increase the risk of developing the disease and a growing number of large rare CNVs; the contribution of these rare CNVs to schizophrenia remains unknown.
MAGRI, Chiara, SACCHETTI, Emilio, TRAVERSA, Michele, VALSECCHI, Paolo, GARDELLA, Rita, Bonvicini, C, MINELLI, Alessandra, GENNARELLI, Massimo, BARLATI, Sergio   +8 more
openaire   +5 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Regional variation in mitochondrial DNA copy number in mouse brain [PDF]

, 2011
Mitochondria have their own DNA (mitochondrial DNA [mtDNA]). Although mtDNA copy number is dependent on tissues and its decrease is associated with various neuromuscular diseases, detailed distribution of mtDNA copies in the brain remains uncertain ...
Kubota-Sakashita, Mie, Mie Kubota-Sakashita, Fuke, Satoshi, Tadafumi Kato, Yasufumi Shigeyoshi, Shigeyoshi, Yasufumi, Kato, Tadafumi, Satoshi Fuke, Kasahara, Takaoki, Takaoki Kasahara   +9 more
core   +1 more source