Results 131 to 140 of about 1,695,985 (356)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Single-cell copy number variation detection [PDF]

, 2011
Detection of chromosomal aberrations from a single cell by array comparative genomic hybridization (single-cell array CGH), instead of from a population of cells, is an emerging technique.
Cheng, Jiqiu, Konings, Peter, Moreau, Yves, Vanneste, Evelyne, Vermeesch, Joris R, Voet, Thierry   +5 more
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Diversity in coding tandem repeats in related spp. [PDF]

, 2003
This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL - © 2003 Jordan et al; licensee BioMed Central Ltd ...
Jordan, P, Saunders, NJ, Snyder, LAS
core   +4 more sources

Detecting single DNA copy number variations in complex genomes using one nanogram of starting DNA and BAC-array CGH [PDF]

, 2004
Marine Guillaud-Bataille
openalex   +1 more source

Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome.

American Journal of Psychiatry, 2017
OBJECTIVE Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia. The aim of this study was to identify additional genetic factors (i.e., "second hits") that may contribute to ...
A. Bassett, Chelsea Lowther, D. Merico, Gregory Costain, E. Chow, Thérèse Van Amelsvoort, D. McDonald-McGinn, R. Gur, A. Swillen, M. V. D. van den Bree, K. Murphy, D. Gothelf, C. Bearden, S. Eliez, W. Kates, N. Philip, V. Sashi, L. Campbell, J. Vorstman, J. Cubells, G. Repetto, T. Simon, E. Boot, T. Heung, Rens Evers, C. Vingerhoets, E. V. van Duin, E. Zackai, E. Vergaelen, K. Devriendt, J. Vermeesch, M. Owen, C. Murphy, Elena Michaelovosky, L. Kushan, Maude Schneider, W. Fremont, T. Busa, S. Hooper, K. McCabe, Sasja N. Duijff, K. Isaev, G. Pellecchia, John Wei, Matthew J. Gazzellone, S. Scherer, B. Emanuel, T. Guo, B. Morrow, C. Marshall   +49 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Accurate measurement of gene copy number for human alpha-defensin DEFA1A3 [PDF]

, 2013
Background: Multi-allelic copy number variants include examples of extensive variation between individuals in the copy number of important genes, most notably genes involved in immune function.
Armour, John A.L., Black, Holly A., Carpenter, Danielle, Khan, Fayeza F., Mansouri, Omniah, Mitchell, Laura, Tyson, Jess   +6 more
core   +3 more sources

Copy number variation in MODY diabetes - Familial case presentation

Genetics & Applications, 2018
MODY (maturity-onset diabetes of the young) is an autosomal dominant form of diabetes that is usually manifested before the 25-year of life. This type of diabetes is caused by defects in the primary insulin secretion.
Naida Lojo-Kadric, Zelija Velija Asimi, Jasmin Ramic, Ksenija Radic, Lejla Pojskic   +4 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source