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Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants

Arthritis &Rheumatology, Volume 78, Issue 3, Page 734-742, March 2026.
Objective Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characterize the diagnostic utility of a plasma ADA2 enzyme activity assay and understand the implications of residual ADA2 ...
Jian Yue +55 more
wiley +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, Volume 16, Issue 2, Page 382-396, February 2026.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source

Laboratory Identification of Lupus Anticoagulant (LA) Using Different Activated Partial Thromboplastin Time (APTT) Assays

International Journal of Laboratory Hematology, Volume 48, Issue 1, Page 172-178, February 2026.
ABSTRACT Introduction The International Society of Thrombosis and Hemostasis (ISTH) guidelines suggest a three‐step evaluation for the detection of lupus anticoagulant (LA), including screening, mixing, and confirmation. According to the guidelines, the LA assay based on activated partial thromboplastin time (APTT) should include an initial screening ...
Bárbara G. Barion +7 more
wiley +1 more source

Female Sex, High Body Mass Index, More Pronounced Femoral Chondral Injury, and Poor Rehabilitation Compliance Were Associated With Medial Meniscus Posterior Root Tears Repair Failure

Arthroscopy, Volume 42, Issue 1, Page 233-243, January 2026.
Purpose To evaluate the risk factors for failure of medial meniscus posterior root repairs, including the preoperative patient factors, surgical factors, and compliance with rehabilitation, excluding already known factors of failure such as uncorrected varus axis deviation and advanced degenerative changes in the medial compartment.
Camilo Partezani Helito +5 more
wiley +1 more source

Analysis of Aspergillus spp. Isolates According to Temporal–Spatial, Sociodemographic, and Clinical Variables—Microsatellite Typing of Clinical and Environmental Samples of Aspergillus fumigatus in a University Hospital in Sao Paulo, Brazil

Mycoses, Volume 69, Issue 1, January 2026.
ABSTRACT Background Typing Aspergillus species is crucial for understanding the sources of infection in hospital environments. Objectives This study analysed clinical and air samples as well as their relationship with the clinical forms of aspergillosis.
Claudia de Abreu Fonseca +18 more
wiley +1 more source

Underestimation of Stent Efficacy: Untreated Artery Events Distort Coronary Intervention Outcomes

Clinical Cardiology, Volume 48, Issue 12, December 2025.
This prospective study evaluated 562 patients with stable coronary disease undergoing PCI. It was observed that 55.8% of events occurred in the treated vessel and 44.2% in untreated vessels. There was no significant difference between bare‐metal and drug‐eluting stents.
Mauricio Rigodanzo Mocha +7 more
wiley +1 more source

Early in‐hospital treatment of acute heart failure. Part 2 of the international expert opinion series on AHF management

ESC Heart Failure, Volume 12, Issue 6, Page 3826-3843, December 2025.
This state‐of‐the‐art review outlines a practical, evidence‐based framework for early acute heart failure management to address critical gaps in current guidance and improve early treatment outcomes. Key components include early identification of co‐existing conditions, bedside haemodynamic profiling, a structured diagnostic approach incorporating both
Anika S. Naidu +22 more
wiley +1 more source

Fechamento percutâneo versus cirúrgico da comunicação interatrial em crianças e adolescentes

Arquivos Brasileiros de Cardiologia, 2013
FUNDAMENTO: Há uma paucidade de dados comparando o método percutâneo e o cirúrgico para tratamento da comunicação interatrial tipo ostium secundum. OBJETIVOS: Análise de segurança e eficácia comparando ambos os métodos de tratamento em um hospital de ...
Rodrigo Nieckel da Costa +9 more
doaj +1 more source

One‐Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT The lingering effects of COVID‐19 may impair survivors' long‐term health‐related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle‐ and low‐income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when ...
Geraldine Trott +55 more
wiley +1 more source

Avaliação e reabilitação vestibular no indivíduo idoso

Revista Brasileira de Geriatria e Gerontologia
Considerando a necessidade de propiciar melhora na qualidade de vida do idoso e a elevada incidência de queixas relacionadas aos transtornos de equilíbrio nessa faixa etária, este estudo teve como objetivo avaliar o equilíbrio estático e dinâmico de ...
Natália Daniela Rezende Mirallas +4 more
doaj +1 more source

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