Results 21 to 30 of about 4,702,161 (344)

Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering

Bioengineering, 2021
Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. It is estimated that more than 17.9 million people die each year due to CVD manifestations.
Panagiotis Mallis, Efstathios Michalopoulos, Catherine Stavropoulos-Giokas   +2 more
doaj   +1 more source

Cord blood maternal microchimerism following unrelated cord blood transplantation

Bone Marrow Transplantation, 2020
Cord blood transplantation (CBT) is associated with low risk of leukemia relapse. Mechanisms underlying antileukemia benefit of CBT are not well understood, however a previous study strongly but indirectly implicated cells from the mother of the cord blood (CB) donor.
Alexandra M Forsyth, Laurel A Thur, Elena Kahn, Oyku Sensoy, Sami B. Kanaan, Colleen Delaney, Colleen Delaney, Koen van Besien, Judy Allen, J. Lee Nelson, J. Lee Nelson, Andromachi Scaradavou, Emma Cousin, Nathalie C. Lambert, Filippo Milano, Filippo Milano   +15 more
openaire   +4 more sources

Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR

Blood, 2019
Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft.
J. Dehn, S. Spellman, C. Hurley, B. Shaw, J. Barker, L. Burns, D. Confer, M. Eapen, M. Fernández-Viña, R. Hartzman, M. Maiers, S. Marino, C. Mueller, M. Perales, R. Rajalingam, J. Pidala   +15 more
semanticscholar   +1 more source

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Cell Death and Disease, 2022
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation.
Meng Kou, Li Huang, Jinjuan Yang, Zhixin Chiang, Shaoxiang Chen, Jie Liu, Liyan Guo, Xiaoxian Zhang, Xiaoya Zhou, Xiang Xu, Xiaomei Yan, Yan Wang, Jinqiu Zhang, Aimin Xu, Hung-fat Tse, Qizhou Lian   +15 more
doaj   +1 more source

Cord Blood Graft Engineering [PDF]

Biology of Blood and Marrow Transplantation, 2013
Once considered solely medical waste and routinely discarded as part of the afterbirth, umbilical cord blood (CB) is now commonly used as a source of hematopoietic stem cells (HSCs) for patients in need of HSC transplantation (HSCT) (or, as more commonly referred to, bone marrow transplantation) for the treatment of both malignant and nonmalignant ...
Colleen Delaney, Catherine M. Bollard, Elizabeth J. Shpall   +2 more
openaire   +3 more sources

Molecular transitions in early progenitors during human cord blood hematopoiesis

Molecular Systems Biology, 2018
Hematopoietic stem cells (HSCs) give rise to diverse cell types in the blood system, yet our molecular understanding of the early trajectories that generate this enormous diversity in humans remains incomplete.
Shiwei Zheng, Efthymia Papalexi, Andrew Butler, William Stephenson, R. Satija   +4 more
semanticscholar   +1 more source

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect.

Blood, 2016
We studied the safety and clinical outcomes of patients treated with umbilical cord blood (UCB)-derived regulatory T cells (Tregs) that expanded in cultures stimulated with K562 cells modified to express the high-affinity Fc receptor (CD64) and CD86, the
C. Brunstein, Jeffrey S. Miller, D. McKenna, K. Hippen, T. Defor, D. Sumstad, J. Curtsinger, M. Verneris, M. MacMillan, B. Levine, J. Riley, C. June, C. Le, D. Weisdorf, P. Mcglave, B. Blazar, J. Wagner   +16 more
semanticscholar   +1 more source

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

Blood, 2017
A small subset of human cord blood CD34+ cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171.
I. Fares, J. Chagraoui, B. Lehnertz, Tara MacRae, N. Mayotte, Elisa Tomellini, L. Aubert, Philippe P Roux, G. Sauvageau   +8 more
semanticscholar   +1 more source

Engineering cord blood to improve engraftment after cord blood transplant [PDF]

Stem Cell Investigation, 2017
Umbilical cord blood transplant (CBT) has traditionally been associated with slower engraftment of neutrophils, delayed immune reconstitution and consequently higher risk of infections as compared with peripheral blood progenitor cell (PBPC) or bone marrow (BM) transplants.
Hema Dave, Catherine M. Bollard, Elizabeth J. Shpall, Rohtesh S. Mehta   +3 more
openaire   +2 more sources

Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation.

Blood, 2016
Successful immune reconstitution (IR) is associated with improved outcomes following pediatric cord blood transplantation (CBT). Usage and timing of anti-thymocyte globulin (ATG), introduced to the conditioning to prevent graft-versus-host disease and ...
R. Admiraal, C. Lindemans, C. van Kesteren, M. Bierings, A. Versluijs, S. Nierkens, J. Boelens   +6 more
semanticscholar   +1 more source