Results 31 to 40 of about 4,702,161 (344)

DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma

Journal of Translational Medicine, 2023
Background This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lung adenocarcinoma (LUAD) cells ...
Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang, Zhi-Jun Pei   +8 more
doaj   +1 more source

Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single‐Center Phase I Open‐Label Trial

Stem Cells Translational Medicine, 2017
Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed. We hypothesized that umbilical cord blood‐derived cell therapies may have potential in alleviating ASD ...
G. Dawson, Jessica M Sun, Katherine S Davlantis, M. Murias, L. Franz, J. Troy, R. Simmons, Maura Sabatos-DeVito, Rebecca Durham, J. Kurtzberg   +9 more
semanticscholar   +1 more source

IL-10+ regulatory B cells are enriched in cord blood and may protect against cGVHD after cord blood transplantation.

Blood, 2016
Cord blood (CB) offers a number of advantages over other sources of hematopoietic stem cells, including a lower rate of chronic graft-versus-host disease (cGVHD) in the presence of increased HLA disparity.
Anushruti Sarvaria, R. Başar, R. Mehta, Hila Shaim, M. Muftuoglu, A. Khoder, T. Sekine, Elif Gokdemir, Kayo Kondo, D. Marin, M. Daher, A. Alousi, A. Alsuliman, E. Liu, B. Oran, A. Olson, Roy B. Jones, U. Popat, C. Hosing, R. Champlin, E. Shpall, K. Rezvani   +21 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Introduction to the Special Issue on Stem Cell and Biologic Scaffold Engineering

Bioengineering, 2019
Tissue engineering and regenerative medicine is a rapidly evolving research field that effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular
Panagiotis Mallis, Catherine Stavropoulos-Giokas, Efstathios Michalopoulos   +2 more
doaj   +1 more source

Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34+ Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Mesenchymal stem cells (MSCs) release hematopoietic cytokines, growth factors, and Microvesicles (MVs) supporting the hematopoietic stem cells (HSCs).
Sara Aqmasheh, Karim Shamsasenjan, Elham Khalaf Adeli, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Davod Pashoutan Sarvar, Hamzeh Timari   +6 more
doaj   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up

Stem Cell Research & Therapy, 2022
Background Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes mellitus that contributes to 85% of nontraumatic lower extremity amputations in diabetic patients.
Che Zhang, Li Huang, Xiaofen Wang, Xiaoya Zhou, Xiaoxian Zhang, Ling Li, Jieying Wu, Meng Kou, Cheguo Cai, Qizhou Lian, Xihui Zhou   +10 more
doaj   +1 more source

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model

PLoS Pathogens, 2016
Epstein-Barr virus (EBV) infection causes B cell lymphomas in humanized mouse models and contributes to a variety of different types of human lymphomas.
Shidong Ma, Xuequn Xu, Richard J. Jones, H. Delecluse, Nicholas A. Zumwalde, Akshat Sharma, J. Gumperz, S. Kenney   +7 more
semanticscholar   +1 more source