Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires [PDF]
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes.
arxiv +1 more source
Background This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lung adenocarcinoma (LUAD) cells ...
Xu-Sheng Liu+8 more
doaj +1 more source
Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants [PDF]
To establish a method that allows for the reliable assessment of vascular endothelial growth factor (VEGF-A) concentrations in very small blood samples of preterm infants. Systemic VEGF measurements are important in view of the most appropriate Anti-VEGF
Lopez Yomayuza, Claudia C.+3 more
core +1 more source
Statistical Analysis of Behavioral Intention Towards Private Umbilical Cord Blood Banking [PDF]
In this paper, we propose a conceptual framework to identify the key dimensions affecting behavioral intention to bank umbilical cord blood in Iran. We examine the impact of awareness, reference group, usability, disease history, and price on perceived risk and behavioral intention to use umbilical cord blood banking service.
arxiv
Family based HLA imputation and optimization of haplo-identical transplants [PDF]
Recently, haplo-identical transplantation with multiple HLA mismatches has become a viable option for system cell transplants. Haplotype sharing detection requires imputation of donor and recipient. We show that even in high-resolution typing when all alleles are known, there is a 15% error rate in haplotype phasing, and even more in low resolution ...
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
wiley +1 more source
Introduction to the Special Issue on Stem Cell and Biologic Scaffold Engineering
Tissue engineering and regenerative medicine is a rapidly evolving research field that effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular
Panagiotis Mallis+2 more
doaj +1 more source
Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34+ Hematopoietic Stem Cells [PDF]
Purpose: Mesenchymal stem cells (MSCs) release hematopoietic cytokines, growth factors, and Microvesicles (MVs) supporting the hematopoietic stem cells (HSCs).
Sara Aqmasheh+6 more
doaj +1 more source
Definition of the cord algebra of knots using Morse Theory [PDF]
We redefine the cord algebra, which was introduced by Lenhard Ng as a topological knot invariant, in terms of Morse Theory. The determination of the cord algebra of the unknot and of the righthanded trefoil are given. We proove that the cord algebra in our definition is a knot invariant.
arxiv +1 more source