Results 51 to 60 of about 4,702,161 (344)

Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)–associated disease (MOGAD). Methods One‐hundred‐nine paediatric MOGAD patients from two UK centres underwent MRI at attack nadir and ...
Ermelinda De Meo, Riccardo Nistri, Michael Eyre, Cheryl Hemingway, Ming Lim, Thomas Rossor, Asthik Biswas, Kshitij Mankad, Ata Siddiqui, Sniya Sudhakar, Declan Chard, Frederik Barkhof, Arman Eshaghi, Olga Ciccarelli, Yael Hacohen   +14 more
wiley   +1 more source

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source

Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study

Bioengineering, 2019
Background: Recent findings have shown that the fibrin gel derived from cord blood units (CBUs) play a significant role in wound healing and tissue regeneration. The aim of this study was to standardize the fibrin gel production process in order to allow
Panagiotis Mallis, Ioanna Gontika, Zetta Dimou, Effrosyni Panagouli, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Eleni Georgiou, Vasiliki Gkioka, Catherine Stavropoulos-Giokas, Efstathios Michalopoulos   +10 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Impact of SARS-CoV-2 infection on the recovery of peripheral blood mononuclear cells by density gradient

Scientific Reports, 2021
SARS-CoV-2 virus infection is responsible for coronavirus disease (COVID-19), which is characterised by a hyperinflammatory response that plays a major role in determining the respiratory and immune-mediated complications of this condition.
Maria D. I. Manunta, Giuseppe Lamorte, Francesca Ferrari, Elena Trombetta, Mario Tirone, Cristiana Bianco, Alessandra Cattaneo, Luigi Santoro, Guido Baselli, Manuela Brasca, Mahnoosh Ostadreza, Elisa Erba, Andrea Gori, Alessandra Bandera, Laura Porretti, Luca V. C. Valenti, Daniele Prati   +16 more
doaj   +1 more source

Cord Blood Transplantation

Apollo Medicine, 2008
Hematopoietic stem cell transplant (HSCT) can be curative for many cancers and inherited non-malignant diseases, including bone marrow failure syndromes, hemoglobinopathies, and inborn errors of metabolism. While, in most settings, matched sibling transplantation confers best results, more than two-thirds of patients lack a suitable donor.
openaire   +2 more sources

The immunobiology of cord blood transplantation [PDF]

The Korean Journal of Hematology, 2010
Despite significant recent advances in the applicability and outcome following unrelated cord blood transplantation (UCBT), infections remain a major cause of mortality associated with poor immune recovery in the first 6 months after UCBT. Enhanced immune reconstitution not only could improve survival by reduced transplant related mortality, but may ...
openaire   +3 more sources

Cardiac troponin T in cord blood [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2001
Perinatal asphyxia is associated with cardiac dysfunction. This may be secondary to myocardial ischaemia. Cardiac troponin T is the ideal marker for myocardial necrosis. Elevated levels in cord blood may be associated with intrauterine hypoxia and increased perinatal morbidity.To establish an upper limit of normal for cardiac troponin T concentration ...
Paul Newland, N V Subhedar, C W Yoxall, S J Clark   +3 more
openaire   +2 more sources

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat, Mehmed B. Bayram, Morgan Paine, Janelle Carnahan, Jian Zhong, Xiaofei Guan, Guang H. Yue, Soha Saleh, Gail F. Forrest   +8 more
wiley   +1 more source

Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia

PLoS ONE, 2016
Objective Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that are involved in fetal growth and development.
R. Su, Chen Wang, Hui Feng, Li Lin, Xinyue Liu, Yumei Wei, Huixia Yang   +6 more
semanticscholar   +1 more source