Results 51 to 60 of about 686,637 (361)

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock [PDF]

, 2015
Hematopoietic stem cells (HSCs) reside in hypoxic niches within bone marrow and cord blood. Yet, essentially all HSC studies have been performed with cells isolated and processed in non-physiologic ambient air.
Bardeesy, Nabeel, Broxmeyer, Hal E., Brustovetsky, Nickolay, Chitteti, Brahmananda R., Cooper, Scott, Falah, Nadia, Fitamant, Julien, Haas, David M., Hangoc, Giao, Huang, XinXin, Ivan, Mircea, Kapur, Reuben, Kim, Kye-Seong, Lee, Man-Ryul, Mantel, Charlie R., Messina-Graham, Steve, O'Leary, Heather A., Pelus, Louis M., Srour, Edward F.   +18 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up

Stem Cell Research & Therapy, 2022
Background Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes mellitus that contributes to 85% of nontraumatic lower extremity amputations in diabetic patients.
Che Zhang, Li Huang, Xiaofen Wang, Xiaoya Zhou, Xiaoxian Zhang, Ling Li, Jieying Wu, Meng Kou, Cheguo Cai, Qizhou Lian, Xihui Zhou   +10 more
doaj   +1 more source

Monoclonal antibodies against human CD34 antigens do not cross-react with ovine umbilical cord blood cells [PDF]

, 2010
CD34 is a cell surface glycoprotein expressed by hematopoietic progenitors and endothelial cells. It is widely used in the clinic for isolation of human hematopoietic stem cells.
Antuofermo, Elisabetta, Bonelli, Piero, Dattena, Maria, Manetti, Roberto, Nicolussi, Paola   +4 more
core   +2 more sources

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Evaluation of Tissue Homogenization to Support the Generation of GMP-Compliant Mesenchymal Stromal Cells from the Umbilical Cord

Stem Cells International, 2016
Recent studies have demonstrated that the umbilical cord (UC) is an excellent source of mesenchymal stromal cells (MSCs). However, current protocols for extracting and culturing UC-MSCs do not meet current good manufacturing practice (cGMP) standards, in
Ryan J. Emnett, Aparna Kaul, Aleksandar Babic, Vicki Geiler, Donna Regan, Gilad Gross, Salem Akel   +6 more
doaj   +1 more source

Evaluation of HLA-G Expression in Multipotent Mesenchymal Stromal Cells Derived from Vitrified Wharton’s Jelly Tissue

Bioengineering, 2018
Background: Mesenchymal Stromal Cells (MSCs) from Wharton’s Jelly (WJ) tissue express HLA-G, a molecule which exerts several immunological properties.
Panagiotis Mallis, Dimitra Boulari, Efstathios Michalopoulos, Amalia Dinou, Maria Spyropoulou-Vlachou, Catherine Stavropoulos-Giokas   +5 more
doaj   +1 more source

A risk factor analysis of outcomes after unrelated cord blood transplantation for children with Wiskott-Aldrich syndrome [PDF]

, 2017
Wiskott-Aldrich syndrome is a severe X-linked recessive immune deficiency disorder. A scoring system of Wiskott-Aldrich syndrome severity (0.5-5) distinguishes 2 phenotypes: X-linked thrombocytopenia and classic Wiskott-Aldrich syndrome.
Alseraihy, Amal, Barriga, Francisco, Bittencourt, Henrique, Boelens, Jaap Jan, Bonfim, Carmem M., Chybicka, Alicja, de Toledo Codina, José Sánchez, Eurocord, Cord Blood Committee of Cellular Therapy and Immunobiology Working Party of the EBMT, Federal University of Parana, Duke University Medical Center and Inborn Errors Working Party of the EBMT, Gennery, Andrew R., Giannotti, Federica, Gluckman, Eliane, Kurtzberg, Joanne, Mellgren, Karin, Nichele, Samantha, O’Brien, Tracey, Page, Kristin M., Rocha, Vanderson, Ruggeri, Annalisa, Shaw, Peter J., Shekhovtsova, Zhanna, Veys, Paul, Volt, Fernanda   +21 more
core   +3 more sources

Impact of respiratory motion on dose distribution in SIB‐SBRT for lung cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Respiratory motion is a major source of dose uncertainty in lung cancer radiotherapy. The dose distribution of simultaneous integrated boost‐stereotactic body radiotherapy (SIB‐SBRT) is inhomogeneous and is significantly impacted by respiratory motion for lung cancer. The effect of respiratory motion on SIB‐SBRT was investigated with a
Lingling Liu, Zhenle Fei, Jie Li, Jiong Shu, Jingyuan Shao, Jianguang Zhang, Xiangli Cui, Hongzhi Wang   +7 more
wiley   +1 more source