Results 61 to 70 of about 4,702,161 (344)

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disorder with limited treatment options. We report a 54‐year‐old female with decade‐long, progressive HAM/TSP, previously refractory to rituximab, who experienced worsening spastic paraparesis and neurogenic bladder dysfunction.
Jiahui Zeng, Wotu Tian, Jingran Yang, Yanping Yang, Li Cao, Xinghua Luan   +5 more
wiley   +1 more source

Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4+ T-cell reconstitution.

Blood Advances, 2017
Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4+-biased T-cell recovery after cord blood transplant. This enhanced T-cell reconstitution differs from that seen after stem cell transplant from other stem cell sources, but the ...
P. Hiwarkar, M. Hubank, W. Qasim, R. Chiesa, K. Gilmour, A. Saudemont, P. Amrolia, P. Veys   +7 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction‐Associated Steatotic Liver Disease via a Galactose‐Modified Supramolecular Near‐Infrared Fluorescent Glycoprobe

Advanced Functional Materials, EarlyView.
A galactose‐modified supramolecular near‐infrared (NIR) glycoprobe, TCF‐FBN@Gal‐BSA, enables targeted delivery to the liver through the asialoglycoprotein receptor (ASGPR) and facilitates liver‐targeting fluorescence visualization of lipid droplets (LDs) in metabolic dysfunction‐associated steatotic liver disease (MASLD) mice.
Han‐Min Wang, Lei Dong, Qiu‐Lian Hao, Lu‐Lu Sun, Xin‐Rong Li, Yu‐Wei Yuan, Ming‐Ye Tang, Jin Gong, Yi Zang, Jia Li, Tony D. James, Xiao‐Peng He, Hai‐Hao Han   +12 more
wiley   +1 more source

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation.

Blood, 2015
Delayed engraftment is a major limitation of cord blood transplantation (CBT), due in part to a defect in the cord blood (CB) cells' ability to home to the bone marrow.
U. Popat, R. Mehta, K. Rezvani, P. Fox, Kayo Kondo, D. Marin, I. Mcniece, B. Oran, C. Hosing, A. Olson, S. Parmar, N. Shah, M. Andreeff, P. Kebriaei, I. Kaur, E. Yvon, M. de Lima, L. Cooper, P. Tewari, R. Champlin, Y. Nieto, B. Andersson, A. Alousi, Roy B. Jones, M. Qazilbash, Q. Bashir, S. Ciurea, Saira S. Ahmed, P. Anderlini, Doyle M Bosque, C. Bollard, J. Molldrem, Julianne J Chen, G. Rondon, Michael Thomas, L. Miller, Steve Wolpe, P. Simmons, S. Robinson, P. Zweidler-McKay, E. Shpall   +40 more
semanticscholar   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Optimization of Decellularization Procedure in Rat Esophagus for Possible Development of a Tissue Engineered Construct

Bioengineering, 2018
Background: Current esophageal treatment is associated with significant morbidity. The gold standard therapeutic strategies are stomach interposition or autografts derived from the jejunum and colon.
Panagiotis Mallis, Panagiota Chachlaki, Michalis Katsimpoulas, Catherine Stavropoulos-Giokas, Efstathios Michalopoulos   +4 more
doaj   +1 more source

Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells.

Blood, 2015
Unrelated cord blood transplantation (CBT) without in vivo T-cell depletion is increasingly used to treat high-risk hematologic malignancies.
P. Hiwarkar, W. Qasim, I. Ricciardelli, K. Gilmour, S. Quezada, A. Saudemont, P. Amrolia, P. Veys   +7 more
semanticscholar   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Wharton’s jelly mesenchymal stem cell-based or umbilical vein endothelial cell-based serum-free coculture with cytokines supports the ex vivo expansion/maintenance of cord blood hematopoietic stem/progenitor cells

Stem Cell Research & Therapy, 2019
Background The umbilical cord blood (UCB) has been widely accepted as an alternative source of hematopoietic stem/progenitor cells (HSPCs) for transplantation, and its use in adults is still restricted because of low absolute numbers.
Qiuyang Li, Dewan Zhao, Qiang Chen, Maowen Luo, Jingcao Huang, Cao Yang, Fangfang Wang, Wenxian Li, Ting Liu   +8 more
doaj   +1 more source