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The Anticancer Properties of Cordycepin and Their Underlying Mechanisms [PDF]
International Journal of Molecular Sciences, 2018 Cordyceps is a genus of ascomycete fungi that has been used for traditional herbal remedies. It contains various bioactive ingredients including cordycepin. Cordycepin, also known as 3-deoxyadenosine, is a major compound and has been suggested to have anticancer potential.
Yoon Jung Park, Soojung Park
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Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris [PDF]
Bioengineering, 2022 C. militaris is an insect-born fungus that belongs to Ascomycota and Cordyceps. It has a variety of biological activities that can be applied in medicine, health-care products, cosmeceuticals and other fields. Cordycepin (COR) is one of the major bioactive components identified from C. militaris. Thus, C.
Zhihong Hu, Bin Zeng
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Cordycepin and kinase inhibition in cancer
Drug Discovery Today, 2023Cordycepin, a nucleoside from Cordyceps mushrooms, has many beneficial properties for health, including anticancer activities. In cancer cells, cordycepin targets various signaling molecules. Here, we review the possible anticancer mechanisms of cordycepin involving the targeting of kinases.
Md Asaduzzaman Khan, Mousumi Tania
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Cordycepin analog of (A2′p) 2 A: Evidence that it functions as a prodrug of cordycepin
Biochemical and Biophysical Research Communications, 1983The effect of the cordycepin trimer analog of (A2'p)2A on cell growth, cell viability and nucleic acid synthesis was assessed in human colon carcinoma cell line HT-29 in vitro. The cordycepin analog, (3'dA2'p)2(3)'dA reduced 24 hr cell growth by 50% at 10(-4)M and decreased cell viability by 98% under these conditions.
M S, Chapekar, R I, Glazer
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Cordycepin as a Metabolite with Pharmacological Potential: A Review
International Journal of Medicinal Mushrooms, 2022The pharmacological values of Cordyceps spp. are substantially associated with the existence of an extremely potent biometabolite: cordycepin. This component exhibits powerful therapeutic activity against cancer, diabetes, and hyperlipidemia and acts as a strong immunomodulator. Extensive pharmaceutical exploitation of Cordyceps spp.
Shivani, Sharma +2 more
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Cordycepin: A bioactive metabolite with therapeutic potential
Life Sciences, 2013Cytotoxic nucleoside analogues were the first chemotherapeutic agents for cancer treatment. Cordycepin, an active ingredient of the insect fungus Cordyceps militaris, is a category of compounds that exhibit significant therapeutic potential. Cordycepin has many intracellular targets, including nucleic acid (DNA/RNA), apoptosis and cell cycle, etc ...
Dharambir Kashyap, Hardeep Singh Tuli
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The effects of cordycepin on malaria parasites
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971Abstract 1. 1. The effects of cordycepin (3′-deoxyadenosine) both on cultures of the erythrocytic stages of Plasmodium knowlesi incubated in vitro and Plasmodium berghei berghei in vivo have been studied. 2. 2. Concentrations of drug as low as 106M affected the growth in vitro of the parasite after a lag period of about 4 hours. These effects
P I, Trigg +2 more
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ANTITUMOUR ACTIVITY OF CORDYCEPIN IN MICE
Clinical and Experimental Pharmacology and Physiology, 2004SUMMARY1. The antitumour effect of orally administered cordycepin, a component isolated from water extracts of Cordyceps sinensis, was examined in mice inoculated with B16 melanoma (B16‐BL6) cells.2. B16‐BL6 (1 × 106) cells were inoculated subcutaneously into the right footpad of mice.
Noriko, Yoshikawa +5 more
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Synthesis of cordycepin: Current scenario and future perspectives
Fungal Genetics and Biology, 2020Cordyceps genus, such as C. militaris and C. kyushuensis, is a source of a rare traditional Chinese medicine that has been used for the treatment of numerous chronic and malignant diseases. Cordycepin, 3'-deoxyadenosine, is a major active compound found in most Cordyceps.
Liyang Yang, Jianquan Guo
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Mitochondrial RNA turnover in the presence of cordycepin
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract Cordycepin inhibits mitochondrial specific RNA synthesis. In contrast to the drug's effect on the nucleolus, no short RNA molecules are produced. After inhibition, prelabeled 12-S and 21-S molecules decay with a 3-h half-life. The mitochondrial 4-S RNA appears stable.
E A, Zylber, S, Perlman, S, Penman
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