Results 171 to 180 of about 5,413 (203)
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Pharmacological and therapeutic potentials of cordycepin in hematological malignancies
Biochemical and Biophysical Research Communications, 2023Hematological malignancies(HMs) are highly heterogeneous diseases with globally rising incidence. Despite major improvements in the management of HMs, conventional therapies have limited efficacy, and relapses with high mortality rates are still frequent.
Zahra Taghinejad +4 more
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Inhibition of human tumor cells by cordycepin
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965Abstract 1. Cordycepin inhibits the growth of human tumor cells (H.Ep. No. 1) grown in culture. The growth inhibition is cytostatic rather than cytocidal. 2. Adenosine competitively prevents inhibition but does not reverse it once it has occurred. This is in accord with the hypothesis that adenosine competes with cordycepin for phosphorylation to ...
M A, RICH +4 more
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Synthesis, antitumor and antibacterial activities of cordycepin derivatives
Journal of Asian Natural Products Research, 2021Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2', 5'-hydroxyl and N6 amino groups of cordycepin. The results showed that the inhibitory activities of 3, 4b, 6c and 6d on A549 were comparable to the positive control gefitinib, and the inhibitory activity of 6a on A549 was better than that of ...
Yu-Ting, Jin +7 more
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Process Biochemistry, 2016
Abstract Cordycepin is an antibiotic with excellent biological and pharmacological activities. In this work, surface imprinting technology was used for cordycepin purification. Gaussian 09 simulation software was used to screen out methacrylic acid and acrylamide as the functional monomers of molecularly imprinted polymers (MIPs).
Yueqian Zhang, Junfen Wan, Xuejun Cao
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Abstract Cordycepin is an antibiotic with excellent biological and pharmacological activities. In this work, surface imprinting technology was used for cordycepin purification. Gaussian 09 simulation software was used to screen out methacrylic acid and acrylamide as the functional monomers of molecularly imprinted polymers (MIPs).
Yueqian Zhang, Junfen Wan, Xuejun Cao
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
Abstract The uptake and metabolism of uniformly 14C-labeled adenosine and the effect of cordycepin (3′-deoxyadenosine) and its 5′-phosphates on Cordyceps militaris have been studied. The uptake of [14C]adenosine by C. militaris was more rapid than the subsequent in vivo phosphorylation, conversion to cordycepin and incorporation into RNA.
B M, Chassy, R J, Suhadolnik
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Abstract The uptake and metabolism of uniformly 14C-labeled adenosine and the effect of cordycepin (3′-deoxyadenosine) and its 5′-phosphates on Cordyceps militaris have been studied. The uptake of [14C]adenosine by C. militaris was more rapid than the subsequent in vivo phosphorylation, conversion to cordycepin and incorporation into RNA.
B M, Chassy, R J, Suhadolnik
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Effects of cordycepin on RNA synthesis in Physarum polycephalum
Archives of Biochemistry and Biophysics, 1975Abstract Cordycepin (100–200 μg/ml) blocked synthesis of all species of RNA separable by gel electrophoresis and by cellulose chromatography, similarly to actinomycin D, but more efficiently and rapidly. At low concentrations (40–80 μ/ml) cordycepin inhibited predominantly ribosomal RNA synthesis in Physarum, like toyocamycin, another adenosine ...
H. Fouquet +4 more
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Synthesis of a c-nucleoside analog of the antibiotic cordycepin
Carbohydrate Research, 1974A C-nucleoside analog of cordycepin, 6-amino-8-(3-deoxy-β-D-erythro-pentofuranosyl)purine (6), has been synthesized. 3-Deoxy-2,5-di-O-(p-nitrobenzoyl)- β-D-erythro-pentofuranosyl bromide reacted with mercuric cyanide in nitromethane to give 2,5-anhydro-4-deoxy-3,6-di-O-(p-nitrobenzoyl)-D-ribo-hexononitrile which, after acid hydrolysis and removal of ...
H S, el-Khadem, E S, el-Ashry
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AIChE Journal
AbstractCordycepin (COR) has attracted extensive attention for its medical value. Currently, separation and extraction from Cordyceps militaris is the main way to obtain COR, but it is time‐consuming and low efficiency. Heterologous synthesis of COR holds great promise for its industrial production. In this work, five COR synthases of different sources
Haibin Wang +4 more
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AbstractCordycepin (COR) has attracted extensive attention for its medical value. Currently, separation and extraction from Cordyceps militaris is the main way to obtain COR, but it is time‐consuming and low efficiency. Heterologous synthesis of COR holds great promise for its industrial production. In this work, five COR synthases of different sources
Haibin Wang +4 more
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Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 1980
M. M. Radwan, H. R. Wilson
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M. M. Radwan, H. R. Wilson
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