Results 211 to 220 of about 9,908 (255)

Multi-omics analysis unravels positive effect of rotenone on the cordycepin production in submerged fermentation of Cordyceps militaris.

Bioresource Technology, 2023
Cordycepin is the key pharmacologically active compound of Cordyceps militaris, and various fermentation strategies have been developed to increase cordycepin production.
You-Chu Ma, P. Huang, Xiao-Ling Wang, Gao-Qiang Liu   +3 more
semanticscholar   +1 more source

Cordycepin analog of (A2′p) 2 A: Evidence that it functions as a prodrug of cordycepin

Biochemical and Biophysical Research Communications, 1983
The effect of the cordycepin trimer analog of (A2'p)2A on cell growth, cell viability and nucleic acid synthesis was assessed in human colon carcinoma cell line HT-29 in vitro. The cordycepin analog, (3'dA2'p)2(3)'dA reduced 24 hr cell growth by 50% at 10(-4)M and decreased cell viability by 98% under these conditions.
M S, Chapekar, R I, Glazer
openaire   +2 more sources

Cordycepin mitigates dextran sulfate sodium-induced colitis through improving gut microbiota composition and modulating Th1/Th2 and Th17/Treg balance.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
BACKGROUND Imbalances in Th1/Th2 and Th17/Treg immune axes, coupled with disruptions in the gut microbiota (GM), play a pivotal role in the pathogenesis of inflammatory bowel disease (IBD).
Zhilin Liu, Shaoxian Wu, Wenting Zhang, Hengwei Cui, Jingfeng Zhang, Xuan Yin, Xiao Zheng, Tao Shen, Hanjie Ying, Lujun Chen, Haitao Wang, Jingting Jiang   +11 more
semanticscholar   +1 more source

Inhibition mechanism of cordycepin and ergosterol from Cordyceps militaris Link. against xanthine oxidase and cyclooxygenase-2.

International Journal of Biological Macromolecules, 2023
Cordyceps militaris Link. (C. militaris) is an entomopathogenic fungus that parasitizes the pupa or cocoon of lepidopteran insect larvae, with various bioactive compounds. Cordycepin and ergosterol are the two active components in C. militaris.
H. B. Zhou, L. Feng, X. Weng, T. Wang, H. Lu, Y. Bian, Z. Huang, J. L. Zhang   +7 more
semanticscholar   +1 more source

Nucleoside antibiotics IV. Metabolic fate of adenosine and cordycepin by Cordyceps militaris during cordycepin biosynthesis

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
Abstract The uptake and metabolism of uniformly 14C-labeled adenosine and the effect of cordycepin (3′-deoxyadenosine) and its 5′-phosphates on Cordyceps militaris have been studied. The uptake of [14C]adenosine by C. militaris was more rapid than the subsequent in vivo phosphorylation, conversion to cordycepin and incorporation into RNA.
B M, Chassy, R J, Suhadolnik
openaire   +2 more sources

Low-carbon and overproduction of cordycepin from methanol using engineered Pichia pastoris cell factory.

Bioresource Technology
Cordycepin, a nucleoside analog, is widely used in medicine and health products. However, the production of cordycepin from Cordyceps militaris faces the challenges of low productivity and high rate of greenhouse gas emissions.
Bingjie Zhao, Yu Li, Yong Zhang, Meixi Pan, Guishen Zhao, Yanbin Guo   +5 more
semanticscholar   +1 more source

Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition.

International Immunopharmacology, 2023
BACKGROUND Thoracic aortic aneurysm (TAA) is a type of common and serious vascular disease, in which inflammation, apoptosis and oxidative stress are strongly involved in the progression.
Minghe Zhou, Zhengbiao Zha, Zhi Zheng, Youmin Pan   +3 more
semanticscholar   +1 more source

Cordycepin‐Loaded Dental Pulp Stem Cell‐Derived Exosomes Promote Aged Bone Repair by Rejuvenating Senescent Mesenchymal Stem Cells and Endothelial Cells

Advanced Healthcare Materials
Aging impairs bone marrow mesenchymal stem cell (BMSC) functions as well as associated angiogenesis which is critical for bone regeneration and repair.
Yu Wang, Shanshan Jin, Yaru Guo, Lisha Zhu, Yilong Lu, Jing Li, Boon C. Heng, Yan Liu, Xuliang Deng   +8 more
semanticscholar   +1 more source

Integrating Synthesis, Physicochemical Characterization, and In Silico Studies of Cordycepin-Loaded Bovine Serum Albumin Nanoparticles.

Journal of Agricultural and Food Chemistry, 2023
Cordycepin gets rapidly metabolized in the body into inactive form due to its structural similarity to adenosine, thus inhibiting its development as a medicinal agent.
Jyoti Jaiswal, A. Srivastav, Pradeep Kumar Rajput, Umesh C. S. Yadav, U. Kumar   +4 more
semanticscholar   +1 more source

Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Cordycepin, the main active component of Cordyceps militaris, exhibits various pharmacological activities, including anti-tumor and antioxidant effects.
Yupeng Wang, Yanhui Deng, Ming-Sheng Feng, Jiaxi Chen, Mengling Zhong, Zhipeng Han, Qi Zhang, Yang Sun   +7 more
semanticscholar   +1 more source