Results 221 to 230 of about 9,908 (255)

The effects of cordycepin on malaria parasites

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971
Abstract 1. 1. The effects of cordycepin (3′-deoxyadenosine) both on cultures of the erythrocytic stages of Plasmodium knowlesi incubated in vitro and Plasmodium berghei berghei in vivo have been studied. 2. 2. Concentrations of drug as low as 106M affected the growth in vitro of the parasite after a lag period of about 4 hours. These effects
P I, Trigg, W E, Gutteridge, J, Williamson   +2 more
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Inhibition of human tumor cells by cordycepin

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965
Abstract 1. Cordycepin inhibits the growth of human tumor cells (H.Ep. No. 1) grown in culture. The growth inhibition is cytostatic rather than cytocidal. 2. Adenosine competitively prevents inhibition but does not reverse it once it has occurred. This is in accord with the hypothesis that adenosine competes with cordycepin for phosphorylation to ...
M A, RICH, P, MEYERS, G, WEINBAUM, J G, CORY, R J, SUHADOLNIK   +4 more
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Synthesis of cordycepin: Current scenario and future perspectives

Fungal Genetics and Biology, 2020
Cordyceps genus, such as C. militaris and C. kyushuensis, is a source of a rare traditional Chinese medicine that has been used for the treatment of numerous chronic and malignant diseases. Cordycepin, 3'-deoxyadenosine, is a major active compound found in most Cordyceps.
Liyang, Yang, Guilan, Li, Zhi, Chai, Qiang, Gong, Jianquan, Guo   +4 more
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Application and research progress of cordycepin in the treatment of tumours (Review)

Molecular Medicine Reports
Cordycepin is a nucleoside molecule found in Cordyceps sinensis and can be obtained through chemical synthesis and biotransformation. Cordycepin has been extensively studied and has been shown to have antitumour activity.
Ru He, Wen Zhou
semanticscholar   +1 more source

Synthesis of surface molecularly imprinting polymers for cordycepin and its application in separating cordycepin

Process Biochemistry, 2016
Abstract Cordycepin is an antibiotic with excellent biological and pharmacological activities. In this work, surface imprinting technology was used for cordycepin purification. Gaussian 09 simulation software was used to screen out methacrylic acid and acrylamide as the functional monomers of molecularly imprinted polymers (MIPs).
Yueqian Zhang, Junfen Wan, Xuejun Cao
openaire   +1 more source

Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis.

Chemico-Biological Interactions
Glioma is a serious primary malignant tumor of the human central nervous system with a poor prognosis and a high recurrence rate; however, inhibition of immune checkpoints can greatly improve the survival rate of patients.
Jing Chen, Ri-Sheng Liang, Bing-Bo Zhuang, Hao Chen, Shuang Liu, Guo-Liang Zhang, Song-Sheng Shi   +6 more
semanticscholar   +1 more source

Mitochondrial RNA turnover in the presence of cordycepin

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Cordycepin inhibits mitochondrial specific RNA synthesis. In contrast to the drug's effect on the nucleolus, no short RNA molecules are produced. After inhibition, prelabeled 12-S and 21-S molecules decay with a 3-h half-life. The mitochondrial 4-S RNA appears stable.
E A, Zylber, S, Perlman, S, Penman
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Cordycepin Enhances the Anticancer Efficacy of PD-L1 Blockade by Modulating the Tumor Microenvironment of Colon Cancer.

European Journal of Pharmacology
BACKGROUND PD-L1 blockade has been found to be effective in treating multiple malignancies. Combined therapy is proposed to provide better therapeutic effects.
Chen Feng, Rongzhang Chen, Xinran Gao, Weiwei Fang, Shaoxian Wu, Lujun Chen, Xiao Zheng, Xinyu Ji, M. Yuan, Yuanyuan Fu, Hanjie Ying, Tao Shen, Dawei Zhu, Jingting Jiang   +13 more
semanticscholar   +1 more source

Effects of cordycepin on RNA synthesis in Physarum polycephalum

Archives of Biochemistry and Biophysics, 1975
Abstract Cordycepin (100–200 μg/ml) blocked synthesis of all species of RNA separable by gel electrophoresis and by cellulose chromatography, similarly to actinomycin D, but more efficiently and rapidly. At low concentrations (40–80 μ/ml) cordycepin inhibited predominantly ribosomal RNA synthesis in Physarum, like toyocamycin, another adenosine ...
H. Fouquet, R. Wick, R. Böhme, H.W. Sauer, K. Scheller   +4 more
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Cordycepin/Hydroxyurea synergy allows low dosage efficacy of cordycepin in MOLT-4 leukemia cells.

Anticancer research, 2007
Cordycepin requires the relatively toxic co-drug, deoxycoformycin, for full efficacy as an anticancer agent. We sought to improve cordycepin efficacy using other, less toxic co-drugs.We evaluated the ability of hydroxyurea (HU) to enhance the effects of cordycepin against MOLT-4 leukemia cells with the MTT cell viability assay.
Hania, Wehbe-Janek, Qiang, Shi, Christopher M, Kearney   +2 more
openaire   +1 more source