Results 71 to 80 of about 3,400 (188)

A generating process of geomagnetic drifting field

Earth, Planets and Space, 2018
The geomagnetic field is comprised of drifting and standing fields. The drifting field has two remarkable features. One is predominance of sectorial harmonics when the field is expressed in a spherical harmonic series, and the other is uniform drift rate
Takesi Yukutake, Hisayoshi Shimizu
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

FeO Content of Earth’s Liquid Core

Physical Review X, 2019
The standard model of Earth’s core evolution has the bulk composition set at formation, with slow cooling beneath a solid mantle providing power for geomagnetic field generation.
Monica Pozzo, Chris Davies, David Gubbins, Dario Alfè   +3 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

The Influence of ɛ‐to‐Py FeOOH Phase Transition on the Lower Mantle Heterogeneities

Geochemistry, Geophysics, Geosystems
Hydrous minerals transported by cold subducting slabs to the lowermost mantle are believed to significantly influence mantle properties and the heterogeneities in the core‐mantle boundary (CMB) region.
Sparsh Sharma, Gaurav Shukla
doaj   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Scattered energy from a rough core‐mantle boundary modeled by a Monte Carlo seismic particle method: Application to PKKP precursors

Geophysical Research Letters, 2016
We stack a large global data set of 1 Hz PKKP waveforms to constrain globally averaged properties of PKKP precursors. We find that the precursor observations are better explained by scattering from core‐mantle boundary (CMB) topography than by scattering
Nicholas Mancinelli, Peter Shearer
doaj   +1 more source

Melting and defect transitions in FeO up to pressures of Earth's core-mantle boundary. [PDF]

Nat Commun, 2023
Dobrosavljevic VV, Zhang D, Sturhahn W, Chariton S, Prakapenka VB, Zhao J, Toellner TS, Pardo OS, Jackson JM.   +8 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Resolving Micrometre‐Scale Zircon Growth in Silicic Systems by 7 μm LA‐MC‐ICP‐MS U‐Pb Dating: Linking Petrology and Geochronology in Silicic Volcanic and Granitic Rocks from Victoria, Australia

Geostandards and Geoanalytical Research, EarlyView.
Key Points 7 μm spot‐diameter LA‐MC‐ICP‐MS analyses yield accurate zircon U‐Pb ages. 1013 Ω amplifier resistors improve low‐signal Pb measurements. Saturn correction protocols minimise down‐hole fractionation effects. We present a systematic evaluation of high spatial‐resolution zircon U‐Pb dating using a Thermo Scientific Neoma multi‐collector ICP‐MS ...
Cristiano Lana, John D. Clemens
wiley   +1 more source