Results 111 to 120 of about 28,187 (286)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Developmental Trajectory of the Operational Momentum Effect

Frontiers in Psychology, 2018
Mental calculation is thought to be tightly related to visuospatial abilities. One of the strongest evidence for this link is the widely replicated operational momentum (OM) effect: the tendency to overestimate the result of additions and to ...
Pedro Pinheiro-Chagas, Pedro Pinheiro-Chagas, Daniele Didino, Vitor G. Haase, Vitor G. Haase, Vitor G. Haase, Vitor G. Haase, Guilherme Wood, Guilherme Wood, André Knops, André Knops, André Knops   +11 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Implication of the lopsided growth for the viscosity of Earth's inner core [PDF]

, 2012
Two main seismic features characterize the Earth's inner core: a North-South polar anisotropy and an East-West asymmetry of P-wave velocity and attenuation. Anisotropy is expected if shear deformation is induced by convective motions.
Alboussiere, Alfe, Amit, Anderson, Aubert, Bergman, Buffett, Buffett, Calvet, Christensen, de Koker, Deguen, Deguen, Deguen, Deguen, Deuss, Dziewonski, Finlay, Gubbins, Hugau Mizzon, Jaupart, Jeanloz, Labrosse, Marc Monnereau, McKenzie, Monnereau, Monnereau, Monnereau, Poirier, Poupinet, Pozzo, Schubert, Stacey, Tanaka, Vočadlo, Weber, Yoshida   +36 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Pharmacological Mechanism of Sancao Yuyang Decoction in the Treatment of Oral Mucositis Based on Network Pharmacology and Experimental Validation

Drug Design, Development and Therapy, 2023
Yunxia Liu,1,* Yun Ye,2,* Guanqun Xie,2 Yefeng Xu,1 Miao Cheng,1 Chunling Li,2 Mengqi Qu,2 Feiye Zhu3 1Oncology Department, Hangzhou Third People’s Hospital, Hangzhou, People’s Republic of China; 2College of Basic Medical Science, Zhejiang ...
Liu Y, Ye Y, Xie G, Xu Y, Cheng M, Li C, Qu M, Zhu F   +7 more
doaj  

Is affect experiencing therapeutic in major depressive disorder? Examining associations between affect experiencing and changes to the alliance and outcome in intensive short-term dynamic psychotherapy. [PDF]

, 2017
Affect experiencing (AE), defined as the facilitation of client in-session bodily arousal and visceral experiencing of affect, is a distinct theoretical process presumed to contribute to therapeutic improvement.
Bradley, S., Falkenström, F., Hardy, G., Salvadori, A., Town, J.M.   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Standaardwoordeboek en kern-woordeboek: 'n Vergelykende evaluering

Lexikos, 2011
<p>OPSOMMING: Hierdie artikel probeer om 'n evaluering te gee van die vierde uitgawe van die Verklarende Handwoordeboek van die Afrikaanse Taal wat in 2000 verskyn het, in vergelyking met Kernwoordeboek, waarvan die eerste uitgawe in 2000 ...
Herman L. Beyer
doaj   +1 more source