Results 81 to 90 of about 28,187 (286)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The adult microbiome of healthy and otitis patients: Definition of the core healthy and diseased ear microbiomes.

PLoS ONE, 2022
Otitis media (OM) and externa (OE) are painful, recurrent ear conditions. As most otitis publications focus on the bacterial content of childhood ears, there remains a dearth of information regarding the adult ear microbiome including both bacteria and ...
Maria Burton, Janina A Krumbeck, Guangxi Wu, Shuiquan Tang, Aishani Prem, Aditya K Gupta, Thomas L Dawson   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Morphology, composition, and mixing state of primary particles from combustion sources — crop residue, wood, and solid waste

Scientific Reports, 2017
Morphology, composition, and mixing state of individual particles emitted from crop residue, wood, and solid waste combustion in a residential stove were analyzed using transmission electron microscopy (TEM).
Lei Liu, Shaofei Kong, Yinxiao Zhang, Yuanyuan Wang, Liang Xu, Qin Yan, A. P. Lingaswamy, Zongbo Shi, Senlin Lv, Hongya Niu, Longyi Shao, Min Hu, Daizhou Zhang, Jianmin Chen, Xiaoye Zhang, Weijun Li   +15 more
doaj   +1 more source

Confirmatory factor analysis of Clinical Outocmes in Routine Evaluation (CORE-OM) used as a measure of emotional distress in people with tinnitus [PDF]

, 2016
BACKGROUND: People with troublesome tinnitus often experience emotional distress. Therefore a psychometrically sound instrument which can evaluate levels of distress and change over time is necessary to understand this experience.
Hall, DA, Handscomb, LE, Hoare, DJ, Shorter, GW   +3 more
core  

Person-centred therapy with a client experiencing social anxiety difficulties : a hermeneutic single case efficacy design [PDF]

, 2011
Social anxiety is a chronic, debilitating psychological condition. Hermeneutic Single Case Efficacy Design (HSCED) is a legalistic mixed-method case study method for evaluating therapy efficacy in single cases. Using a case of Person-Centred Therapy (PCT)
Elliott, Robert, Macleod, Rachel, Stephen, Susan   +2 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Domestic violence and mental health:a cross-sectional survey of women seeking help from domestic violence support services [PDF]

, 2016
BACKGROUND: Domestic violence and abuse (DVA) are associated with increased risk of mental illness, but we know little about the mental health of female DVA survivors seeking support from domestic violence services.
Agnew-Davies, Roxane, Bailey, Jayne E, Feder, Gene S, Ferrari, Giulia, Howard, Louise M, Howarth, Emma, Peters, Tim J, Sardinha, Lynnmarie   +7 more
core   +6 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Estimating a preference-based index from the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM): valuation of CORE-6D [PDF]

Background: The Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) is used to evaluate the effectiveness of psychological therapies in people with common mental disorders.
Barkham, M, Brazier, JE, Mavranezouli, I, Rowen, D   +3 more
core