Results 81 to 90 of about 28,720 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Climate-Provenance Effect on the Organic Matter Enrichment of the Chang 9 Source Rocks in the Central Ordos Basin, China

open access: yesGeofluids, 2021
The Upper Triassic Chang 9 organic-rich sediments have been considered as effective hydrocarbon source rocks for the Mesozoic petroleum system in the Ordos Basin.
Ling Ma, Zhihuan Zhang, Weiqiu Meng
doaj   +1 more source

Confirmatory factor analysis of Clinical Outocmes in Routine Evaluation (CORE-OM) used as a measure of emotional distress in people with tinnitus [PDF]

open access: yes, 2016
BACKGROUND: People with troublesome tinnitus often experience emotional distress. Therefore a psychometrically sound instrument which can evaluate levels of distress and change over time is necessary to understand this experience.
Hall, DA   +3 more
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Investigating invariant item ordering in the Mental Health Inventory : an illustration of the use of different methods [PDF]

open access: yes, 2014
Invariant item ordering is a property of scales whereby the items are scored in the same order across a wide range of the latent trait and across a wide range of respondents.
Meijer, Rob R.   +3 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Morphology, composition, and mixing state of primary particles from combustion sources — crop residue, wood, and solid waste

open access: yesScientific Reports, 2017
Morphology, composition, and mixing state of individual particles emitted from crop residue, wood, and solid waste combustion in a residential stove were analyzed using transmission electron microscopy (TEM).
Lei Liu   +15 more
doaj   +1 more source

Domestic violence and mental health:a cross-sectional survey of women seeking help from domestic violence support services [PDF]

open access: yes, 2016
BACKGROUND: Domestic violence and abuse (DVA) are associated with increased risk of mental illness, but we know little about the mental health of female DVA survivors seeking support from domestic violence services.
Agnew-Davies, Roxane   +7 more
core   +7 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Estimating a preference-based index from the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM): valuation of CORE-6D [PDF]

open access: yes
Background: The Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) is used to evaluate the effectiveness of psychological therapies in people with common mental disorders.
Barkham, M   +3 more
core  

Home - About - Disclaimer - Privacy