Results 161 to 170 of about 3,820,570 (317)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

EES 2550 Earth History Core General Education Assessment, 2018-2019

, 2019
This report assesses Wright State University\u27s course EES 2550, Earth History, as part of the institution’s ongoing general education Core assessment ...
College of Science and Mathematics, Wright State University
core  

MTH 2300 Calculus I Core General Education Assessment, 2019-2020

, 2020
This report assesses Wright State University\u27s course MTH 2300, Calculus I, as part of the institution’s ongoing general education Core assessment ...
College of Science and Mathematics, Wright State University
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preliminary Effectiveness of the Comprehensive Oncology Rehabilitation and Exercise (CORE) Clinical Workflow Algorithm on Health Outcomes During Nonmetastatic Breast Cancer Care. [PDF]

Int J Breast Cancer
Simon LH, Saviers-Steiger C, Dunston ER, Zickmund SL, Hansen PA, Ulrich CM, LaStayo PC, Steinberg D, Noren CS, Finch A, Seckinger L, Braun E, Chipman J, Oza S, Brownson KE, Coletta AM.   +15 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

FAS 1050 Amish Society Core General Education Assessment, 2017-2018

, 2018
This report assesses Wright State University\u27s course FAS 1050, Amish Society, as part of the institution’s ongoing general education Core assessment ...
College of Liberal Arts, Wright State University
core  

Boosting Biomedical Research Capacity: The Role of INBRE-Supported Core Facility Vouchers in IDeA States. [PDF]

J Biomol Tech
Lessard LM, Duncan MK.
europepmc   +1 more source

MIPco=coRE

CoRR
In 2020, a landmark result by Ji, Natarajan, Vidick, Wright, and Yuen showed that MIP*, the class of languages that can be decided by a classical verifier interacting with multiple computationally unbounded provers sharing entanglement in the tensor product model, is equal to RE. We show that the class MIPco, a complexity class defined similarly to MIP*
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source