Results 1 to 10 of about 195,125 (123)

UPLC-Q-TOF/MS, network pharmacology, molecular docking, and experimental validation to explore the mechanisms of toad clothing on rheumatoid arthritis [PDF]

Scientific Reports
Toad clothing (toad slough) detoxifies, reduces oedema and analgesia, is anti-inflammatory and anti-tumour, and regulates the immune system. Toad clothing’s mechanism is unclear.
Ting Wang, Haixiong Xia, Jingyi Zhu, Mingyou Yu, Ziyi Zhang, Junhou Lu, Wei Zhou, Jianwei Xu   +7 more
doaj   +2 more sources

Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]

, 2010
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller, AD Ellington, AI Nesvizhskii, Alana Sterkel, Alex Stewart, Alexey Wolfson, Allison Weiss, Andrew B. Dalby, AS Levey, AS Levey, Ashley Bock, Ashley Forbes, AW Bell, B Schweitzer, BE Eaton, Bharat Gawande, Brian Hicke, Bridget Lollo, Britta Singer, Bruce E. Eaton, C Borrebaeck, C Tuerk, Cate Fowler, Chi Zhang, Christopher Bock, D Schneider, D Venturoli, D Zichi, D Zichi, Dan Nieuwlandt, Daniel I. Resnicow, Daniel Levine, Daniel Schneider, Deborah Ayers, Dennis Halladay, Dom Zichi, Dylan Flather, Edward N. Brody, EN Brody, ES Gragoudas, Evaldas Katilius, Fabrizio Gelain, Glenn Sanders, Gregory Husar, HK Binz, IC van Riemsdijk-van Overbeeke, J Ninio, J Ruckman, J Silberring, JD Vaught, JD Vaught, Jeff Carter, Jeffrey J. Walker, Jennifer Bertino, Jim Heil, JJ Hopfield, Joe Heilig, John Rohloff, Jonathan D. Vaught, K Chaudhary, L Gold, L Liotta, LA Gugliotti, LA Stevens, Larry Gold, Luke Kroiss, M Famulok, M Pascual, Magda Gunn, Malti Nikrad, Martin Stanton, Matt Otis, Meredith Goss, Michele Nelson, Mike Mehan, Mike Vrkljan, Mike Watrobka, Nancy Kim, Nebojsa Janjic, Ngan Le, P Mitchell, R Aebersold, R Craig, R Vanholder, Rachel M. Ostroff, RD Jenison, RF Service, RM Ostroff, Robert Mehler, S Fredriksson, S Pan, SA Doggrell, Sally K. Nelson, Sarah Sattin, Shashi Gupta, Sheela Waugh, Sheri K. Wilcox, Stephan Kraemer, Steve Pietrasiewicz, Steven K. Wolk, Susan Jennings, Suzanne Stratford, SV Giannelli, T Dewey, TA Addona, Tad H. Koch, Thale Jarvis, Thomas Parker, Tim Fitzwater, TL Nickolas, TM Tarasow, Tracy R. Keeney, Trudi Foreman, Urs Ochsner, Wes Lindsey, Wes Mayfield   +115 more
core   +16 more sources

miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes

Adipocyte, 2022
Obesity is a major global health issue that contributes to the occurrence of metabolic disorders. Based on this fact, understanding the underlying mechanisms and to uncover promising therapeutic approaches for obesity have attracted intense investigation.
Xiaoqiong Tan, Tingting Zhu, Linqiang Zhang, Lin Fu, Ying Hu, Huiqin Li, Chengbin Li, Jingjing Zhang, Bin Liang, Jing Liu   +9 more
doaj   +1 more source

Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation [PDF]

Molecular and Cellular Biology, 1998
The polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor (CBF) is a transcription factor composed of two subunits, alpha and beta. The gene encoding the beta subunit is disrupted by inv(16), resulting in the formation of a chimeric protein, beta-SMMHC, which is associated with acute myelogenous leukemia.
Y, Kanno, T, Kanno, C, Sakakura, S C, Bae, Y, Ito   +4 more
openaire   +2 more sources

Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia

Journal of Hematology & Oncology, 2021
Background B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is the most common pediatric cancer. Identifying key players involved in proliferation of BCP-ALL cells is crucial to propose new therapeutic targets. Runt Related Transcription Factor 1 (
Hélène Jakobczyk, Lydie Debaize, Benoit Soubise, Stéphane Avner, Jérémie Rouger-Gaudichon, Séverine Commet, Yan Jiang, Aurélien A. Sérandour, Anne-Gaëlle Rio, Jason S. Carroll, Christian Wichmann, Michael Lie-a-Ling, Georges Lacaud, Laurent Corcos, Gilles Salbert, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec   +17 more
doaj   +1 more source

Generation of RUNX1-null reporter human embryonic stem cell line GIBHe008-A

Stem Cell Research, 2020
RUNX1/AML1/CBFA2 (runt-related transcription factor 1/acute myeloid leukemia 1 protein/core-binding factor subunit alpha-2), is a transcription factor that plays a critical role in the development of normal hematopoiesis.
Hanif Ullah, Hao You, Zahir Shah, Chenyu Fan, Baoyun Zhang, Hao Liu, Jianguang Zhang, Nasir Abbas, Elena S. Filonenko, Igor M. Samokhvalov   +9 more
doaj   +1 more source

CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]

, 2008
Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core   +2 more sources

Intrinsic Transcriptional Activation-Inhibition Domains of the Polyomavirus Enhancer Binding Protein 2/Core Binding Factor α Subunit Revealed in the Presence of the β Subunit

Molecular and Cellular Biology, 1998
A member of the polyomavirus enhancer binding protein 2/core binding factor (PEBP2/CBF) is composed of PEBP2 alphaB1/AML1 (as the alpha subunit) and a beta subunit. It plays an essential role in definitive hematopoiesis and is frequently involved in the chromosomal abnormalities associated with leukemia.
T, Kanno, Y, Kanno, L F, Chen, E, Ogawa, W Y, Kim, Y, Ito   +5 more
openaire   +3 more sources

Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation [PDF]

, 2008
Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor ...
Berman, C.-K. Chen, Chan, Chen, Chen, Chen, Coleman, De Vries, Grafstein-Dunn, He, Heximer, K. C. Slep, Kimple, Koelle, Kozasa, Kozasa, Kudlacek, Lodowski, M. A. Kercher, M. I. Simon, McIntire, Neubig, Noel, P. B. Sigler, Slep, Snow, Sondek, Sunahara, T. Wieland, Tesmer, Tesmer, Valenzuela, Wang, Wilkie, Willars   +34 more
core   +4 more sources