Results 21 to 30 of about 193,524 (221)

The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]

, 2016
Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan, Lewko, Dawid, Majsterek, Ireneusz, Nowak, Alicja, Pytel, Dariusz, Rozpędek, Wioletta   +5 more
core   +2 more sources

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]

, 2019
The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica, Astaburuaga, Rosario, Basti, Alireza, Genov, Nikolai, Relógio, Angela   +4 more
core   +1 more source

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]

, 2012
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M, Bann JG, Barnhart MM, Dodson KW, Dodson KW, Doublie S, Gong M, Griebling TL, Henderson NS, Hess B, Holmgren A, Hooton TM, Hultgren SJ, Hung DL, Hung DL, Hung DL, Jacob-Dubuisson F, Jones CH, Justice SS, Kabsch W, Knight SD, Kuehn MJ, Kuehn MJ, Leslie A, Martinez JJ, Munera D, Nishiyama M, Painter J, Pellecchia M, Phan G, Remaut H, Remaut H, Roberts JA, Roberts JA, Rose RJ, Sauer FG, Sauer FG, Sauer FG, Saulino ET, Saulino ET, Sheldrick GM, Slonim LN, Striker R, Stromberg N, Verger D, Verger D, Volkan E, Wright KJ, Zavialov AV   +48 more
core   +2 more sources

Changes in gene and protein expression related to feed intake and thermoregulation in broilers challenged with different doses of mixed Eimeria spp

Poultry Science
The objective of the study was to investigate the effects of Eimeria infection on expression of genes and proteins related to feed intake and core body temperature in broilers.
Janghan Choi, Jihwan Lee, Woo Kyun Kim
doaj   +1 more source

Comparative proteomics of uropathogenic Escherichia coli during growth in human urine identify UCA-like (UCL) fimbriae as an adherence factor involved in biofilm formation and binding to uroepithelial cells [PDF]

, 2015
Uropathogenic Escherichia coli (UPEC) are the primary cause of urinary tract infection (UTI) in humans. For the successful colonisation of the human urinary tract, UPEC employ a diverse collection of secreted or surface-exposed virulence factors ...
Allsopp, LP, Moriel, DG, Schembri, MA, Totsika, M, Webb, RI, Wurpel, DJ   +5 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Identifying disulfidptosis-related biomarkers in epilepsy based on integrated bioinformatics and experimental analyses

Neurobiology of Disease
One of the underlying mechanisms of epilepsy (EP), a brain disease characterized by recurrent seizures, is considered to be cell death. Disulfidptosis, a proposed novel cell death mechanism, is thought to play a part in the pathogenesis of epilepsy, but ...
Sijun Li, Lanfeng Sun, Hongmi Huang, Xing Wei, Yuling Lu, Kai Qian, Yuan Wu   +6 more
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Transcription, signaling receptor activity, oxidative phosphorylation, and fatty acid metabolism mediate the presence of closely related species in distinct intertidal and cold-seep habitats [PDF]

, 2015
Bathyal cold seeps are isolated extreme deep-sea environments characterized by low species diversity while biomass can be high. The Hakon Mosby mud volcano (Barents Sea, 1,280 m) is a rather stable chemosynthetic driven habitat characterized by prominent
Derycke, Sofie, Van Belleghem, Steven, Van Campenhout, Jelle, Vanreusel, Ann   +3 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source