Results 1 to 10 of about 193,524 (221)

CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), with data on DNA, on the protein encoded, and where the gene is implicated.
AJ Bais
openalex   +3 more sources

miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes

Adipocyte, 2022
Obesity is a major global health issue that contributes to the occurrence of metabolic disorders. Based on this fact, understanding the underlying mechanisms and to uncover promising therapeutic approaches for obesity have attracted intense investigation.
Xiaoqiong Tan, Tingting Zhu, Linqiang Zhang, Lin Fu, Ying Hu, Huiqin Li, Chengbin Li, Jingjing Zhang, Bin Liang, Jing Liu   +9 more
doaj   +1 more source

Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation [PDF]

Molecular and Cellular Biology, 1998
The polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor (CBF) is a transcription factor composed of two subunits, alpha and beta. The gene encoding the beta subunit is disrupted by inv(16), resulting in the formation of a chimeric protein, beta-SMMHC, which is associated with acute myelogenous leukemia.
Y, Kanno, T, Kanno, C, Sakakura, S C, Bae, Y, Ito   +4 more
openaire   +2 more sources

Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia

Journal of Hematology & Oncology, 2021
Background B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is the most common pediatric cancer. Identifying key players involved in proliferation of BCP-ALL cells is crucial to propose new therapeutic targets. Runt Related Transcription Factor 1 (
Hélène Jakobczyk, Lydie Debaize, Benoit Soubise, Stéphane Avner, Jérémie Rouger-Gaudichon, Séverine Commet, Yan Jiang, Aurélien A. Sérandour, Anne-Gaëlle Rio, Jason S. Carroll, Christian Wichmann, Michael Lie-a-Ling, Georges Lacaud, Laurent Corcos, Gilles Salbert, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec   +17 more
doaj   +1 more source

Generation of RUNX1-null reporter human embryonic stem cell line GIBHe008-A

Stem Cell Research, 2020
RUNX1/AML1/CBFA2 (runt-related transcription factor 1/acute myeloid leukemia 1 protein/core-binding factor subunit alpha-2), is a transcription factor that plays a critical role in the development of normal hematopoiesis.
Hanif Ullah, Hao You, Zahir Shah, Chenyu Fan, Baoyun Zhang, Hao Liu, Jianguang Zhang, Nasir Abbas, Elena S. Filonenko, Igor M. Samokhvalov   +9 more
doaj   +1 more source

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Systematic identification of gene families for use as markers for phylogenetic and phylogeny- driven ecological studies of bacteria and archaea and their major subgroups [PDF]

, 2013
With the astonishing rate that the genomic and metagenomic sequence data sets are accumulating, there are many reasons to constrain the data analyses.
Eisen, Jonathan A., Jospin, Guillaume, Wu, Dongying   +2 more
core   +12 more sources

Pebp2/cbf, the Murine Homolog of the Human Myeloid Aml1 and Pebp2-Beta/cbf-Beta Proto-Oncoproteins, Regulates the Murine Myeloperoxidase and Neutrophil Elastase Genes in Immature Myeloid Cells [PDF]

, 1994
The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer.
Nuchprayoon, I., Meyers, S, Scott, L. M., Suzow, J., Hiebert, S., Friedman, A. D.   +5 more
core   +2 more sources

Intrinsic Transcriptional Activation-Inhibition Domains of the Polyomavirus Enhancer Binding Protein 2/Core Binding Factor α Subunit Revealed in the Presence of the β Subunit

Molecular and Cellular Biology, 1998
A member of the polyomavirus enhancer binding protein 2/core binding factor (PEBP2/CBF) is composed of PEBP2 alphaB1/AML1 (as the alpha subunit) and a beta subunit. It plays an essential role in definitive hematopoiesis and is frequently involved in the chromosomal abnormalities associated with leukemia.
T, Kanno, Y, Kanno, L F, Chen, E, Ogawa, W Y, Kim, Y, Ito   +5 more
openaire   +3 more sources

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature [PDF]

, 2017
The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression ...
Bush, Erin C, Gutmann, David H, Ma, Yu, Pan, Yuan, Sims, Peter A, Solga, Anne C, Toonen, Joseph A   +6 more
core   +2 more sources