Results 261 to 270 of about 240,084 (355)

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Efficacy of Computerized Tomography-Guided Core Biopsy in Identifying the Subtypes of Lung Adenocarcinoma: An Observational Perspective From Pakistan. [PDF]

Cureus
Yasin B, Saeed H, Ahmad MA, Najam S, Niazi M, Tariq H, Khan AYY, Khaliq S, Zaidi SGEZ, Mehmood Qadri H.   +9 more
europepmc   +1 more source

Assessment of 1183 screen-detected, category 3B, circumscribed masses by cytology and core biopsy with long-term follow up data [PDF]

, 2008
Gelareh Farshid, Peter Downey, P. Grantley Gill, Steve Pieterse   +3 more
openalex   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

MP30-20 POSITIVE PRE-BIOPSY MULTIPARAMETRIC MRI OF THE PROSTATE: CAN WE RESTRICT BIOPSY TO MRI-TARGETED CORES ONLY? [PDF]

, 2019
Christophe K. Mannaerts, Amir Kajtazovic‘s, Olivia Lodeizen, Maudy Gayet‘s, Marc Engelbrecht, Gerrit Jager‘s, Hessel Wijkstra, Theo de Reijke, Harrie P. Beerlage   +8 more
openalex   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Ultrasound-guided core needle biopsy of nodular lesions of the spleen in hematology clinical practice [PDF]

Alessandro Broccoli, Sofia Maria Bakken, Lisa Argnani, Camilla Mazzoni, Davide Di Benedetto, Marta Machado, Livia Masi, Nicola Venturoli, Daniela Agostinelli, Beatrice Casadei, Gabriele Gugliotta, Cinzia Pellegrini, Vittorio Stefoni, Carla Serra, Pier Luigi Zinzani   +14 more
openalex   +1 more source

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
Super‐resolution microscopy identifies nano‐sized tau aggregates (nano‐aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age‐Related Tauopathy, and Alzheimer's disease brains. Morphology and hyperphosphorylation signatures distinguish physiological from pathological forms, with nano ...
Adriana N. Santiago‐Ruiz, Siewert Hugelier, Gabriela L. Correa, Charles R. Bond, Edward B. Lee, Melike Lakadamyali   +5 more
wiley   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Factors affecting the success of CT-guided core biopsy of musculoskeletal lesions with a 13-G needle. [PDF]

Skeletal Radiol
Gataa KG, Inci F, Szaro P, Geijer M.
europepmc   +1 more source