Results 51 to 60 of about 622,972 (290)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The First Two Years of FLEET: An Active Search for Superluminous Supernovae

The Astrophysical Journal, 2023
In 2019 November, we began operating Finding Luminous and Exotic Extragalactic Transients (FLEET), a machine-learning algorithm designed to photometrically identify Type I superluminous supernovae (SLSNe) in transient alert streams.
Sebastian Gomez, Edo Berger, Peter K. Blanchard, Griffin Hosseinzadeh, Matt Nicholl, Daichi Hiramatsu, V. Ashley Villar, Yao Yin   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Prospects for Extending the Core-collapse Supernova Detection Horizon Using High-energy Neutrinos

The Astrophysical Journal, 2023
Large neutrino detectors like IceCube monitor for core-collapse supernovae using low-energy (MeV) neutrinos with a detection reach from a supernova neutrino burst to the Magellanic Cloud. However, some models predict the emission of high-energy neutrinos
Nora Valtonen-Mattila, Erin O’Sullivan
doaj   +1 more source

The Gravitational Wave Signature of Core-Collapse Supernovae

, 2009
We review the ensemble of anticipated gravitational-wave (GW) emission processes in stellar core collapse and postbounce core-collapse supernova evolution.
Ott, Christian D.
core   +1 more source

Hydrogen-Rich Core-Collapse Supernovae [PDF]

, 2016
Hydrogen-rich core collapse supernovae, known as "Type II" supernovae, are the most common type of stellar explosion realized in nature. They are defined by the presence of prominent hydrogen lines in their spectra. Type II supernovae are observed only in star-forming galaxies, and several events have been directly linked to massive star progenitors ...
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Infant Core-collapse Supernovae with Circumstellar Interactions from KMTNet. I. Luminous Transitional Case of KSP-SN-2022c

The Astrophysical Journal
We present BVi multiband high-cadence observations of a Type II supernova (SN) KSP-SN-2022c from a star-forming galaxy at z ≃ 0.041 from its infant to nebular phase. Early light-curve fitting with a single power law is consistent with the first detection
Nan Jiang, Dae-Sik Moon, Yuan Qi Ni, Maria R. Drout, Hong Soo Park, Santiago González-Gaitán, Sang Chul Kim, Youngdae Lee, Ernest Chang   +8 more
doaj   +1 more source

Models of Millimeter and Radio Emission from Interacting Supernovae

The Astrophysical Journal, 2022
This work utilizes established models of synchrotron-powered light curves for core-collapse supernovae in dense circumstellar environments, namely, type IIn and Ibn, to demonstrate the potential for detecting millimeter emission from these events.
Nitika Yadlapalli Yurk, Vikram Ravi, Anna Y. Q. Ho   +2 more
doaj   +1 more source

Critical Conditions for Core-Collapse Supernovae [PDF]

Physical Review Letters, 2012
The explosion of a core-collapse supernova can be approximated by the breakdown of steady-state solutions for accretion onto a proto-neutron star (PNS). We analytically show that as the neutrino luminosity exceeds a critical value L_c, the neutrinosphere pressure exceeds the hydrostatic limit even for an optimal shock radius R.
Keshet, Uri, Balberg, Shmuel
openaire   +3 more sources