Results 161 to 170 of about 760,524 (299)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Practice of core competence training for orthopedic nurses in Hunan Province of China. [PDF]

BMC Nurs
Zhou Y, Guo Y, Huang L, Zeng B.
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Development of a core competence model for improving medical college students' ability in respond to public health emergencies. [PDF]

Front Public Health
Liu F, Huang S, Chen F, Yang S, Wu L, Lin Y, He B, Hu Z.   +7 more
europepmc   +1 more source

THE CORE OF COMPETENCE [PDF]

Occupational Medicine, 1999
openaire   +2 more sources

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Developing and validating the Chinese nursing core competence scale for tertiary hospital nurses based on evolving health care needs in China. [PDF]

BMC Nurs
Chen M, Li X, Wang A, Zhou B.
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Family therapy : a necessary core competence for psychiatric trainees [PDF]

, 2018
A Barbato, A Burkhouse, A Carr, A Heru, A Heru, A Holtom-Viesel, A Schaub, A Tetley, B McCrady, B Soenens, B Wijngaarden Van, C Carr, C Prescott, D Fergusson, D Grange Le, D Hartnett, D Kavanaugh, D Maybery, E Berman, F Paola Di, F Reiss, G Diamond, G Lemmens, H Handa, H Liddle, H Snoeck, J Alonso, J Lebow, J Reid, K McLaughlin, K McLaughlin, L Berg, L Depestele, M Oud, M Vansteenkiste, M Yap, O Transvag, P Rhys, R Anda, R William, S Beach, S Dwyer, S Henggeler, S Johnson, S Priebe, S Wiebe, SM Glynn, T Jewell, U Rehman, V Morgan, W Beardslee, W McFarlane   +51 more
core   +2 more sources

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source