ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
<i><b>Streptococcus dentisani</b></i> <b>7746 encodes a cocktail of 14 bacteriocins associated with Com and Blp-like quorum sensing regulatory systems</b>. [PDF]
Revilla-Guarinos A +9 more
europepmc +1 more source
Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini +8 more
wiley +1 more source
Cuteness conquest: how cuteness type and brand impression affect consumers' brand evaluation in social media. [PDF]
Wang J, Zhou J, Shen J, Wang X.
europepmc +1 more source
This paper proposes a hierarchical reconfigurable metasurface architecture (HRMA) to achieve comprehensive electromagnetic parameter modulation and on‐demand polymorphic function switching. The reconfigurable metasurface is divided into a programmable core (PC) and scenario‐guided functional modules (FMs), exhibiting significant flexibility and ...
Lihao Zhu +11 more
wiley +1 more source
Program Directors Survey on Competency Assessment in Cardiology Fellowship. [PDF]
Cullen MW +9 more
europepmc +1 more source
PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su +7 more
wiley +1 more source
Boundary conditions for foreign language talent public service output. [PDF]
Yang F, Chen C, Li H.
europepmc +1 more source
A Spin‐Texture Spin‐Valves With Van Der Waals Magnets
ABSTRACT All‐electrical methods for nucleating, detecting, and manipulating spin textures in 2D van der Waals (vdW) magnets can serve as fundamental building blocks for multi‐state spintronic memory, logic, and neuromorphic computing applications.
Bing Zhao +3 more
wiley +1 more source
Educational anxiety triggered by artificial intelligence technology: pathways and configuration analysis affecting teachers' professional well-being. [PDF]
Wan Q, Zhang H, Cao J, Tao H.
europepmc +1 more source

