Results 21 to 30 of about 2,423,246 (283)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The current status and influencing factors of core competencies among China’s internet-based “sharing nurses” based on social-ecological system theory: a multicenter cross-sectional study

Frontiers in Medicine
AimsThis study aims to investigate the current status of core competencies and emergency response competencies among Chinese sharing nurses, examine the correlation between core competencies and emergency response competencies, and identify the factors ...
Wang Yudong, Xing Zhaowei, Jiao Linlin, Zhang Yishu, Wu Jianghua, Yang Linlin, Yang Chunling   +6 more
doaj   +1 more source

Core Competencies Theory: A Plan for Knowledge and Information Science Education [PDF]

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2015
Purpose: The aim of this study was to evaluate competency-based training concepts, introduce core competencies and to apply these concepts as a conceptual model for knowledge and information science education in Iran.
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doaj  

Health services research doctoral core competencies

BMC Health Services Research, 2009
This manuscript presents an initial description of doctoral level core competencies for health services research (HSR). The competencies were developed by a review of the literature, text analysis of institutional accreditation self-studies submitted to ...
Holve Erin, Martin Diane P, Forrest Christopher B, Millman Anne   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Core competencies required of project managers

South African Journal of Business Management, 2000
Project management is internationally recognised as a management tool that is critical for success in the current work environment. In South Africa, initiatives are under way to produce internationally acceptable education and certification standards for
Michael Birkhead, Margaret Sutherland, Tudor Maxwell   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A RESOURCES-BASED VIEW OF A MEDICAL DEVICES COMPANY IN INDONESIA [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2019
The purpose of this study was to analyze the core competencies of a medical devices company in Indonesia. Based on the resource-based view, distinct core competencies derive the company's competitive advantage compared to its competitors.
Fazrullah M., Jahroh S., Kirbrandoko
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Element 3 Core Assessment Plan Template Core General Education Assessment, 2017-2018

, 2018
The Core Assessment Plan Template for Element 3 - Interdisciplinary Global Studies as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +2 more sources