Results 121 to 130 of about 3,873,112 (365)

clonevdjseq: A workflow and bioinformatics management system for sequencing, archiving, and analysis of VDJ sequences from clonal libraries

BMC Bioinformatics
Background Advances in next-generation sequencing technologies have facilitated extensive analysis of B cell and T cell receptor (BCR/TCR, respectively) sequences from monoclonal hybridoma libraries, single B cells, and single T cells, generating vast ...
Keith Mitchell, Samuel Hunter, Lutz Froenicke, Karl Murray, Matthew Settles, James S. Trimmer   +5 more
doaj   +1 more source

Insertion of sequences at the original provirus integration site of mouseROSA26 locus using the CRISPR/Cas9 system

FEBS Open Bio, 2015
Targeted transgenic mouse models, where an exogenous gene is inserted into a specified genomic locus to achieve its stable and reliable expression, have been widely used in biomedical research.
Rolen M. Quadros, Donald W. Harms, Masato Ohtsuka, Channabasavaiah B. Gurumurthy   +3 more
doaj   +1 more source

Naegleria genus pangenome reveals new structural and functional insights into the versatility of these free-living amoebae

Frontiers in Microbiology, 2023
IntroductionFree-living amoebae of the Naegleria genus belong to the major protist clade Heterolobosea and are ubiquitously distributed in soil and freshwater habitats. Of the 47 Naegleria species described, N. fowleri is the only one being pathogenic to
Alexis Dereeper, Nina Allouch, Vincent Guerlais, Maëlle Garnier, Laurence Ma, Johan F. De Jonckheere, Sandeep J. Joseph, Ibne Karim M. Ali, Antoine Talarmin, Isabel Marcelino   +9 more
doaj   +1 more source

Development of ListeriaBase and comparative analysis of Listeria monocytogenes [PDF]

, 2015
Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to ...
Ang, Mia Yang, Choo, Siew Woh, Dutta, Avirup, Heydari, Hamed, Mutha, Naresh VR, Siow, Cheuk Chuen, Tan, Mui Fern, Tan, Shi Yang, Wee, Wei Yee, Wong, Guat Jah   +9 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors

Scientific Reports
Breast cancer is a prevalent and significant cause of mortality in women, and manifests as six molecular subtypes. Its further histologic classification into non-invasive ductal or lobular carcinoma (DCIS) and invasive carcinoma (ILC or IDC) underscores ...
Vasiliki Pantazi, Vanda Miklós, Paul Smith, Orsolya Oláh-Németh, Gabriella Pankotai-Bodó, Divya Teja Dondapati, Ferhan Ayaydin, Vincenzo D’Angiolella, Tibor Pankotai   +8 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms [PDF]

Nature, 2018
Abstract The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The
Grohme, Markus Alexander, Schloissnig, Siegfried, Rozanski, Andrei, Pippel, Martin, Young, George Robert, Winkler, Sylke, Brandl, Holger, Henry, Ian, Dahl, Andreas, Powell, Sean, Hiller, Michael, Myers, Eugene, Rink, Jochen Christian   +12 more
openaire   +4 more sources

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Nature Communications, 2019
ATP can function as a biological hydrotrope, but its global effects on protein solubility have not yet been characterized. Here, the authors quantify the effect of ATP on the thermal stability and solubility of the cellular proteome, providing insights ...
Sindhuja Sridharan, Nils Kurzawa, Thilo Werner, Ina Günthner, Dominic Helm, Wolfgang Huber, Marcus Bantscheff, Mikhail M. Savitski   +7 more
doaj   +1 more source

Whole-genome comparative analysis of virulence genes unveils similarities and differences between endophytes and other symbiotic bacteria

Frontiers in Microbiology, 2015
Plant pathogens and endophytes co-exist and often interact with the host plant and within its microbial community. The outcome of these interactions may lead to healthy plants through beneficial interactions, or to disease through the inducible ...
Sebastian eLòpez-Fernàndez, Paolo eSonego, Marco eMoretto, Michael ePancher, Kristof eEngelen, Ilaria ePertot, Andrea eCampisano   +6 more
doaj   +1 more source