Results 91 to 100 of about 3,231,062 (301)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Preparation and Characterization of MnFe2O4/Fe Soft Magnetic Composites by Surface Oxidation
MetalsMnFe2O4/Fe soft magnetic composites (SMCs) were designed by the surface oxidation method, and the MnFe2O4 layer was utilized as the insulation coating.
Shigeng Li, Rutie Liu, Xiang Xiong
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A Temperature-Corrected High-Frequency Non-Sinusoidal Excitation Core Loss Prediction Model
MagnetochemistryPredicting core loss under high-frequency non-sinusoidal excitation is crucial for power electronics equipment design. Temperature significantly affects core loss, and traditional core loss prediction models typically incorporate temperature corrections ...
Jingwen Zhang +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Mass Loss: Its Effect on the Evolution and Fate of High-Mass Stars
, 2014 Our understanding of massive star evolution is in flux, due to recent upheavals in our view of mass loss, and observations of a high binary fraction among O-type stars. Mass-loss rates for standard metallicity-dependent winds of hot stars are now thought
Smith, Nathan
core +1 more source
Hotspots, mantle plumes and core heat loss [PDF]
Earth and Planetary Science Letters, 2002 Abstract The heat flux at the core–mantle boundary (CMB) is a key parameter for core dynamics since it controls its cooling. However, it is poorly known and estimates range from 2 TW to 10 TW. The lowest bound comes from estimates of buoyancy fluxes of hotspots under two assumptions: that they are surface expression of mantle plumes originating from ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Advanced Materials in Engineering, 2018 In this study, iron powder (~45 μm) with the minimum purity of 99% was insulated by the 1 to 4 wt% sodium silicate insulator (SiO2.3Na2O solution in 40 wt% water) and the 0.5 wt% zinc stearate.
M. Amoohadi +3 more
doaj
Modeling and Testing of 3D Wound Core Loss of Amorphous Alloy Transformer for Photovoltaic Inverter
EnergiesThe harmonic content of transformers used in the field of new energy is significantly higher than that of conventional transformers, leading to an abnormal increase in transformer loss during operation.
Peng Chen +8 more
doaj +1 more source