Results 71 to 80 of about 1,082,336 (265)
Material Selection Analysis of Rail Grinding Train Isolation Transformer Core
机车电传动, 2019 According to the circuit of power supply system for grinding motor of double power rail grinding train, the requirement of selecting material for isolating transformer core was put forward.
Xiangling CHEN, Xiyou HUANG
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Calculation and analysis of losses of magnetic-valvecontrollable reactor
Journal of Measurement Science and Instrumentation, 2020 Magnetic-valve controllable reactor（MCR） has characteristics of DC bias and different types of magnetic flux density in the magnetic circuit and winding current distortion.
ZHANG Hui-ying +3 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nonlinearity Estimation and Compensation for Accurate PMSM Modeling and Voltage Prediction
CES Transactions on Electrical Machines and SystemsFor permanent magnet synchronous machine (PMSM), the machine model is critical to predict the operating states for motor control, which, however, can be greatly affected by system nonlinearities.
Beichen Ding +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Hotspots, mantle plumes and core heat loss [PDF]
Earth and Planetary Science Letters, 2002 Abstract The heat flux at the core–mantle boundary (CMB) is a key parameter for core dynamics since it controls its cooling. However, it is poorly known and estimates range from 2 TW to 10 TW. The lowest bound comes from estimates of buoyancy fluxes of hotspots under two assumptions: that they are surface expression of mantle plumes originating from ...
openaire +2 more sources