Results 91 to 100 of about 1,017,148 (266)

Research on Deterioration Mechanism and High-Precision Modelling of the Core Loss for Amorphous Alloys after Wire-Cut Electric Discharge Machining. [PDF]

Materials (Basel), 2023
Yang X, Qiu S, Wang Y, Zhao P, Gao Y, Wang H, Zhang C.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Electron energy loss spectroscopy database synthesis and automation of core-loss edge recognition by deep-learning neural networks. [PDF]

Sci Rep, 2022
Kong L, Ji Z, Xin HL.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preparation and Characterization of MnFe₂O₄/Fe Soft Magnetic Composites by Surface Oxidation

Metals
MnFe2O4/Fe soft magnetic composites (SMCs) were designed by the surface oxidation method, and the MnFe2O4 layer was utilized as the insulation coating.
Shigeng Li, Rutie Liu, Xiang Xiong
doaj   +1 more source

Fe-Based Amorphous Magnetic Powder Cores with Low Core Loss Fabricated by Novel Gas-Water Combined Atomization Powders. [PDF]

Materials (Basel), 2022
Liu J, Dong Y, Zhu Z, Zhao H, Pang J, Wang P, Zhang J.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Temperature-Corrected High-Frequency Non-Sinusoidal Excitation Core Loss Prediction Model

Magnetochemistry
Predicting core loss under high-frequency non-sinusoidal excitation is crucial for power electronics equipment design. Temperature significantly affects core loss, and traditional core loss prediction models typically incorporate temperature corrections ...
Jingwen Zhang, Cunhao Lu, Jian Chen, Yaoji Deng   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Influence of Magnetic Slot Wedges on the Flux Density and Losses of Large Variable Speed Pumped Storage Generator-Motor

Journal of Harbin University of Science and Technology
In order to study the influence of magnetic slot wedge on the flux density and losses in the large variable speed pumped storage generator-motors, a two-dimensional electromagnetic field finite element model of 326 MW variable speed pumped storage ...
HAN Jichao, ZHANG Yong, QI Haiming, Sun Yutian, HU Gang, ZHANG Chunli   +5 more
doaj   +1 more source