Results 131 to 140 of about 143,179 (310)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Numerical and experimental comparison of the no-load losses in the different grain-oriented electrical steel materials

e-Prime: Advances in Electrical Engineering, Electronics and Energy
One of the critical pieces of equipment for power transmission and distribution is the transformer. The operation of the transformers is essential for the power supply's continued stability and efficacy. With an increase in rated power, the transformer's
Kamran Dawood, Semih Tursun
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Predicting core losses in power converters based on open source database

IET Power Electronics
Core losses are closely related to flux densities, frequencies, temperatures, exciting waveforms, and DC biases. Hysteresis losses and dynamic losses are considered the main components of core losses.
Yan Zhou, Minmin Zhang
doaj   +1 more source

Losses and orbital part of the Poynting vector of air-core modes in hollow-core fibers

Компьютерная оптика
In our earlier works, we investigated a relationship between the formation of vortices in the transverse component of the Poynting vector of core modes and the regimes of strong localization of these modes in solid core micro-structured optical fibers ...
G.K. Alagashev, S.S. Stafeev, A.D. Pryamikov   +2 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Magnetic Properties of Electrical Steel, Power Transformer Core Losses and Core Design Concepts

, 2017
The work presented in this PhD-thesis includes the measurement of electrical steel\u27s properties as well as the simulation of power transformer core losses and leads to the investigation of new core design ...
Freitag, Christian
core   +1 more source

Losses and Energy Backflows of the Fundamental Core Mode in Solid Core Micro Structured Optical Fibers

Photonics
This work discusses the behavior of transverse energy fluxes of the fundamental core mode of a holey fibers and a photonic band gap fibers when the polarization state of this mode changes.
Andrey Pryamikov
doaj   +1 more source