Results 131 to 140 of about 898,016 (304)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Predicting core losses in power converters based on open source database

IET Power Electronics
Core losses are closely related to flux densities, frequencies, temperatures, exciting waveforms, and DC biases. Hysteresis losses and dynamic losses are considered the main components of core losses.
Yan Zhou, Minmin Zhang
doaj   +1 more source

Losses and orbital part of the Poynting vector of air-core modes in hollow-core fibers

Компьютерная оптика
In our earlier works, we investigated a relationship between the formation of vortices in the transverse component of the Poynting vector of core modes and the regimes of strong localization of these modes in solid core micro-structured optical fibers ...
G.K. Alagashev, S.S. Stafeev, A.D. Pryamikov   +2 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Losses and Energy Backflows of the Fundamental Core Mode in Solid Core Micro Structured Optical Fibers

Photonics
This work discusses the behavior of transverse energy fluxes of the fundamental core mode of a holey fibers and a photonic band gap fibers when the polarization state of this mode changes.
Andrey Pryamikov
doaj   +1 more source

How Should Monetary Policy Respond to Changes in the Relative Price of Oil? Considering Supply and Demand Shocks. [PDF]

This paper examines optimal monetary policy in a New Keynesian model where the relative price of oil is affected by exogenous supply shocks and a productivity-driven demand shock.
MICHAEL PLANTE
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Magnetic core effects on the high-frequency behavior of transformers

International Journal of Electrical Power & Energy Systems
This paper investigates the high-frequency transformer losses attributed to eddy currents in both conductors and the core. A comprehensive model of a transformer winding is presented, meticulously incorporating skin and proximity effects.
Farzad Nasirpour, Mohamad Ghaffarian Niasar, Marjan Popov   +2 more
doaj   +1 more source