Results 111 to 120 of about 2,316,046 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improved calculation of core losses of high-speed motors with two different permanent magnets considering higher order current harmonics

AIP Advances
In high-speed permanent magnet synchronous motor drives, time harmonics in the current occur owing to the carrier frequency of the inverter, which affects the core losses among the electromagnetic losses.
Sang-Hyeop Kim, Jong-Hyeon Woo, Yong-Joo Kim, Jang-Young Choi, Kyung-Hun Shin   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Numerical and experimental comparison of the no-load losses in the different grain-oriented electrical steel materials

e-Prime: Advances in Electrical Engineering, Electronics and Energy
One of the critical pieces of equipment for power transmission and distribution is the transformer. The operation of the transformers is essential for the power supply's continued stability and efficacy. With an increase in rated power, the transformer's
Kamran Dawood, Semih Tursun
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

2020 Core Assessment Report [PDF]

, 2020
This report contains data across Wright State University course sections that were part of the 2020 Core ...
Wright State University
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Defining and Computing Equivalent Inductances of Gapped Iron Core Reactors

, 2011
The paper revisits the fundamental definitions and explores computational alternatives of equivalent inductances of gapped iron core reactors. Unlike in a transformer, the physical meaning of component inductances of a reactor is subject to uncertainty ...
Rotaru, Mihai, Donuk, Atilla, Rotaru, M., Donuk, A., Sykulski, Jan K., Sykulski, J.K.   +5 more
core   +1 more source

Predicting core losses in power converters based on open source database

IET Power Electronics
Core losses are closely related to flux densities, frequencies, temperatures, exciting waveforms, and DC biases. Hysteresis losses and dynamic losses are considered the main components of core losses.
Yan Zhou, Minmin Zhang
doaj   +1 more source