Results 101 to 110 of about 2,316,046 (304)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Microstructure, soft magnetic properties and applications of amorphous Fe-Co-Si-B-Mo-P alloy
AIP Advances, 2018 DC thermomagnetic properties of Fe51Co12Si16B8Mo5P8 amorphous alloy in the as-quenched and after annealing below crystallization temperature are investigated.
Mariusz Hasiak +4 more
doaj +1 more source
High-Frequency Gap Losses in Nanocrystalline Cores
IEEE Transactions on Power Electronics, 2017 Finite element analysis is used to examine the gap losses that occur in finely laminated nanocrystalline inductor cores under high-frequency operation. The losses are seen to be concentrated in the region of the air gap and the dependence of the losses on key design parameters and operating conditions is explored.
Wang, Yiren +2 more
openaire +1 more source
Element 3 Chairs and Course List Core General Education Assessment, 2017-2018
, 2018 The Chairs and Course List for Element 3 - Interdisciplinary Global Studies as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Research and analysis of different grades silicon steels for an ultra-high-speed PM motor [PDF]
AIP AdvancesUltra-high-speed permanent magnet motors (UHSPMMs) operate at extremely high rotational speeds, which results in a very high operating frequency in the stator core.
Ruilin Pei +3 more
doaj +1 more source
Hotspots, mantle plumes and core heat loss [PDF]
Earth and Planetary Science Letters, 2002 Abstract The heat flux at the core–mantle boundary (CMB) is a key parameter for core dynamics since it controls its cooling. However, it is poorly known and estimates range from 2 TW to 10 TW. The lowest bound comes from estimates of buoyancy fluxes of hotspots under two assumptions: that they are surface expression of mantle plumes originating from ...
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Electromagnetic Fields, Power Losses, and Resistance of High-Frequency Magnetic Devices [PDF]
, 2010 The operation of dc-dc PWM converters requires magnetic components that operate at high frequencies and carry large currents. At such frequencies the skin and proximity effects cause a substantial increase in power losses and ac resistance.
Whitman, Daniel Joseph
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source