Results 91 to 100 of about 5,396,651 (301)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

No-Core Shell Model for Nuclear Systems with Strangeness

, 2013
We report on a novel ab initio approach for nuclear few- and many-body systems with strangeness. Recently, we developed a relevant no-core shell model technique which we successfully applied in first calculations of lightest $\Lambda$ hypernuclei.
Gazda, D., Mareš, J., Navrátil, P., Roth, R., Wirth, R.   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Granulation in K-type Dwarf Stars. II. Hydrodynamic simulations and 3D spectrum synthesis

, 2009
We construct a 3D radiative-hydrodynamic model atmosphere of parameters Teff = 4820 K, log g = 4.5, and solar chemical composition. The theoretical line profiles computed with this model are asymmetric, with their bisectors having a characteristic C ...
Allende Prieto, Allende Prieto, Asplund, Asplund, Asplund, Asplund, Barklem, Blackwell, Borrero, C. Allende Prieto, Collet, Collet, D. L. Lambert, Dravins, Dravins, Dravins, Dravins, Freytag, Gilliland, Gray, Gray, Gray, Gray, Gray, Gray, Gray, Grevesse, Gustafsson, Gustafsson, Hubeny, Hubeny, I. Ramírez, Janssen, Koesterke, Kurucz, L. Koesterke, Ludwig, M. Asplund, Mihalas, Nordlund, Ramírez, Ramírez, Robinson, Stein, Trampedach, Vögler   +45 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling

Nature Communications
K2P2.1 (gene: Kcnk2), a two-pore-domain potassium channel, regulates leukocyte transmigration across the blood-brain barrier by a yet unknown mechanism. We demonstrate that Kcnk2 −/− mouse brain microvascular endothelial cells (MBMECs) exhibit an altered
Stefanie Lichtenberg, Laura Vinnenberg, Falk Steffen, Isabelle Plegge, Nicholas Hanuscheck, Vera Dobelmann, Joel Gruchot, Christina B. Schroeter, Haribaskar Ramachandran, Beatrice Wasser, Derya Bachir, Christopher Nelke, Jonas Franz, Christoph Riethmüller, Stefan Tenzer, Ute Distler, Christina Francisca Vogelaar, Kristina Kusche-Vihrog, Boris V. Skryabin, Timofey S. Rozhdestvensky, Albrecht Schwab, Jean Krutmann, Andrea Rossi, Thomas Budde, Stefan Bittner, Sven G. Meuth, Tobias Ruck   +26 more
doaj   +1 more source

Stool DNA testing for early detection of colorectal cancer: systematic review using the HTA Core Model^® for Rapid Relative Effectiveness Assessment. [PDF]

Ger Med Sci, 2023
Stürzlinger H, Conrads-Frank A, Eisenmann A, Invansits S, Jahn B, Janzic A, Jelenc M, Kostnapfel T, Mencej Bedrac S, Mühlberger N, Siebert U, Sroczynski G, European Network for Health Technology Assessment (EUnetHTA).   +12 more
europepmc   +1 more source