Results 71 to 80 of about 18,005,559 (248)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Skillful subseasonal ensemble predictions of heat wave onsets through better representation of land surface uncertainties

npj Climate and Atmospheric Science
Uncertainties in land surface processes notably limit subseasonal heat wave (HW) onset predictions. A better representation of the uncertainties in land surface processes using ensemble prediction methods may be an important way to improve HW onset ...
Qiyu Zhang, Mu Mu, Guodong Sun
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Element 3 Chairs and Course List Core General Education Assessment, 2017-2018

, 2018
The Chairs and Course List for Element 3 - Interdisciplinary Global Studies as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +1 more source

Tdrd15 is dispensable for male fertility and spermatogenesis in the golden hamster

European Journal of Medical Research
Tudor domain-containing proteins (TDRDs) constitute an evolutionarily conserved protein family and are critical for germline development and piRNA pathway regulation, with established roles in male fertility.
Miao Zhu, Yijian Xiang, Haodong Wang, Shanmeizi Zhao, Wentao Zeng, Jianmin Li, Bing Yao   +6 more
doaj   +1 more source

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

Frontiers in Immunology
With the prevalence of sequentially-emerged sublineages including BA.1, BA.2 and BA.5, SARS-CoV-2 Omicron infection has transformed into a regional epidemic disease.
Wenqi Wang, Wenqi Wang, Qiushi Jin, Qiushi Jin, Ruixue Liu, Ruixue Liu, Wentao Zeng, Pengfei Zhu, Pengfei Zhu, Tingting Li, Tingting Li, Tiecheng Wang, Haiyang Xiang, Hang Zhang, Qin Chen, Yun Gao, Yana Lai, Fang Yan, Xianzhu Xia, Xianzhu Xia, Jianmin Li, Xuefeng Wang, Yuwei Gao, Yuwei Gao   +23 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Nature Communications, 2019
In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate ...
Ting-Ting Du, James B. Dewey, Elizabeth L. Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P. Francis, Edward Perez-Reyes, Stacey J. Guillot, Nicholas E. Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar, Jung-Bum Shin   +13 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Element 3 Assessment Report Template Core General Education Assessment, 2017-2018

, 2018
The Assessment Report Template for Element 3 - Interdisciplinary Global Studies as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core   +1 more source