Results 61 to 70 of about 18,005,559 (248)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

MODEL OF ONTOLOGICAL SYSTEM WITH REFLEXIVE CORE

Открытое образование (Москва), 2016
The structure of multilevel ontological system is described in the article. This model is used for planning linguistic problems in the «OntoIntegrator» system.
Olga A. Nevzorova, Vladimir N. Nevzorov
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Inverse problem for the Earth's core evolution model

Russian Journal of Earth Sciences, 2020
The size and the age of the inner core impose constraints in modeling of the Earth's core evolution. The origin of the solid core corresponds to the change in convection regime in the core and, correspondingly, to the change in the magnetic field ...
Reshetnyak M Yu
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

MORF4L1, encoding a chromatin remodeler, is mutated in a recognizable dysmorphic neurodevelopmental disorder

Scientific Reports
Chromatin remodelers are increasingly recognized as key contributors to neurodevelopmental disorders, usually through de novo dominant variants. Mortality Factor 4 Like 1 (MORF4L1) is recognized for its role in chromatin organization and transcriptional ...
Hanan E. Shamseldin, Dana Marafi, Mohammed AlMuhaizea, C’airah Ceolin, Firdous Abdulwahab, Tarfa Alshidi, Buthaina Albash, Fatemah Alabdulrazzaq, Harsha R. Murthy, Jenica L. M. Van Gennip, Isabella M. Harmic, Rebecca Simonian, Xiucheng Cui, Jason Burgess, Brian Ciruna, Ashish R. Deshwar, Fowzan S. Alkuraya, Lama AlAbdi   +17 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis

Cell Reports
Summary: Cancer cells rely on lipogenesis in addition to exogenous lipid uptake, and fatty acid synthase (FASN) is aberrantly overexpressed in myeloid leukemia, yet its role in leukemogenesis is unclear. We show that FASN is essential for leukemogenesis.
Meng Su, Qinglin Li, Zhiyi Lv, Xinshu Xie, Yating Lu, Yaohui He, Hanqi Liu, Hui Cao, Jie Ouyang, Qiao Zhang, Xuezhen Ma, Yexin Yang, Ailing Zou, Kang Liu, Shuqian Xu, Ji Li, Lili Chen, Xin Lu, Jie Yang, Caiming Wu, Lu Liu, Lei Zhang, Yue Sheng, Yong Huang, Yang Mei   +24 more
doaj   +1 more source