Results 51 to 60 of about 3,973,532 (276)

Network analysis of core symptom changes in Chinese patients undergoing radical prostatectomy for prostate cancer: a longitudinal study

Frontiers in Oncology
ObjectiveTo construct symptom networks at different time points during the early postoperative period in patients undergoing radical prostatectomy and to identify the core symptom at each stage.MethodsThis longitudinal study used convenience sampling to ...
Xin Huang, Xiaoqin Huang, Xiaoqin Huang, Xiaoqin Huang, Yiqin Shi, Wang Li, Guihong Zheng   +6 more
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Symptom structure of PTSD: support for a hierarchical model separating core PTSD symptoms from dysphoria [PDF]

European Journal of Psychotraumatology, 2012
As of yet, no collective agreement has been reached regarding the precise factor structure of posttraumatic stress disorder (PTSD). Several alternative factor-models have been proposed in the last decades.The current study examined the fit of a hierarchical adaptation of the Simms et al.
Rademaker, Arthur R., van Minnen, Agnes, Ebberink, Freek, van Zuiden, Mirjam, Hagenaars, Muriel A., Geuze, Elbert   +5 more
openaire   +4 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Exploring core and sentinel symptoms in elderly patients with type 2 diabetes through network analysis and the Apriori algorithm

Frontiers in Medicine
ObjectiveTo construct the symptom network of elderly patients with type 2 diabetes mellitus (T2DM) and perform association rule analysis for each symptom cluster, identify core symptoms, and explore the sentinel symptoms, to provide references for ...
Tingting Tan, Tingting Tan, Chongyao Yang, Qingqing Wang, Qingqing Wang, Cong Xu, Cong Xu, Sijing Wang, Bingbing Xiao, Bingbing Xiao, Jing Zhao, Jing Zhao, Huan He, Miaoqin Wang   +13 more
doaj   +1 more source

Depression symptoms and core affect: Results from network and regression analyses

Mental Health Science, 2023
Depression is measured in most studies by surveys that sum individual symptom scores into one common variable. Given the high heterogeneity of depressive disorders and the diversity of symptom profiles at the same levels of depression, a significant ...
Edmunds Vanags, Malgožata Raščevska
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source