Results 111 to 120 of about 2,482,416 (214)

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Predicted brain-regional gene expression patterns in individuals living with Alzheimer's disease. [PDF]

Neurobiol Aging
Razavi A, Hou J, Lin SJ, Zhang C, Kremen WS, Fennema-Notestine C, Elman J, Holmans P, Faraone SV, Gaiteri C, Hess JL, Glatt SJ.   +11 more
europepmc   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Psychiatric and neurological predictors of early ADHD medication discontinuation across the lifespan: a multinational study. [PDF]

BMJ Ment Health
Brikell I, Astrup A, Wimberley T, Araki M, Chang Z, Demontis D, Dong Z, Faraone SV, Gao L, Gillies MB, Haavik J, Hartman C, Larsson H, Man KKC, Pearson SA, Snieder H, Vos M, Wong ICK, Yao H, Yuen AS, Zhang-James Y, Zhou Y, Zoega H, Engeland A, Dalsgaard S, Klungsøyr K.   +25 more
europepmc   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

A foul odor from the mesozoic: early evolution of scent gland defense in pentatomomorphan true bugs (Hemiptera: Heteroptera). [PDF]

BMC Biol
Dai R, Du S, Ren D, Engel MS, Yao Y.
europepmc   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

The Impact of Untreated Attention-Deficit/Hyperactivity Disorder on Motor Vehicle Accidents: A Systematic Review and Meta-Analysis. [PDF]

Adv Ther
Childress A, Malik H, Potenziano J.
europepmc   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Multilayer Bioinspired Heterogeneous Superelastic Ceramic Aerogel for Robust Signal Detection Under Extreme High-Temperature Conditions. [PDF]

Small
Li X, Guo Y, Zhu W, Guo Q, Liu M, Zhang L, Shen X, Shen J, Zhang Y, Dai Z, Yan J.   +10 more
europepmc   +1 more source